Are there, or shall we discover, biomarkers to guide PD-1 inhibition?

Paolo A. Ascierto, Ramon Andrade De Mello

Research output: Contribution to journalReview articlepeer-review


Paolo A Ascierto and Ramon A de Mello speak to Ellen Clarke, Commissioning Editor Despite the recent success of PD-1/PD-L1-directed immunotherapy in a number of different malignancies, there are currently no effective biomarkers available to predict patient response to treatment. This question is particularly important because these immunotherapy agents are expensive and have significant toxicity profiles. Early data are emerging on biomarkers such as PD-L1 expression; however, it is clear that further studies are needed to identify alternative biomarkers and to improve understanding of the host immune system and tumor microenvironment. In a panel interview Paolo Ascierto and Ramon de Mello discuss this important clinical question.

Original languageEnglish
Pages (from-to)681-686
Number of pages6
Issue number6
Publication statusPublished - Jun 1 2016


  • checkpoint inhibitors
  • PD-L1
  • predictive biomarkers

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology


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