Are there two different forms of functional dystonia? A multimodal brain structural MRI study: Molecular Psychiatry

A. Tomic, F. Agosta, E. Sarasso, I. Petrovic, S. Basaia, D. Pesic, M. Kostic, A. Fontana, V.S. Kostic, M. Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

This study assessed brain structural alterations in two diverse clinical forms of functional (psychogenic) dystonia (FD) – the typical fixed dystonia (FixFD) phenotype and the “mobile” dystonia (MobFD) phenotype, which has been recently described in one study. Forty-four FD patients (13 FixFD and 31 MobFD) and 43 healthy controls were recruited. All subjects underwent 3D T1-weighted and diffusion tensor (DT) magnetic resonance imaging (MRI). Cortical thickness, volumes of gray matter (GM) structures, and white matter (WM) tract integrity were assessed. Normal cortical thickness in both FD patient groups compared with age-matched healthy controls were found. When compared with FixFD, MobFD patients showed cortical thinning of the left orbitofrontal cortex, and medial and lateral parietal and cingulate regions bilaterally. Additionally, compared with controls, MobFD patients showed reduced volumes of the left nucleus accumbens, putamen, thalamus, and bilateral caudate nuclei, whereas MobFD patients compared with FixFD demonstrated atrophy of the right hippocampus and globus pallidus. Compared with both controls and MobFD cases, FixFD patients showed a severe disruption of WM architecture along the corpus callous, corticospinal tract, anterior thalamic radiations, and major long-range tracts bilaterally. This study showed different MRI patterns in two variants of FD. MobFD had alterations in GM structures crucial for sensorimotor processing, emotional, and cognitive control. On the other hand, FixFD patients were characterized by a global WM disconnection affecting main sensorimotor and emotional control circuits. These findings may have important implications in understanding the neural substrates underlying different phenotypic FD expression levels. © 2018, Springer Nature Limited.
Original languageEnglish
Pages (from-to)3350-3359
Number of pages10
JournalMol. Psychiatry
Volume25
Issue number12
DOIs
Publication statusPublished - 2020

Keywords

  • adult
  • Article
  • basal ganglion
  • brain atrophy
  • caudate nucleus
  • cell disruption
  • clinical article
  • controlled study
  • cortical thickness (brain)
  • diffusion tensor imaging
  • dystonia
  • emotion
  • executive function
  • functional dystonia
  • globus pallidus
  • gray matter
  • hippocampus
  • human
  • middle aged
  • multimodal imaging
  • nuclear magnetic resonance imaging
  • nucleus accumbens
  • orbital cortex
  • phenotype
  • priority journal
  • putamen
  • pyramidal tract
  • sensorimotor function
  • thalamus
  • thalamus anterior nucleus
  • white matter

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