Are we not over-estimating the prevalence of coeliac disease in the general population?

Research output: Contribution to journalArticle

Abstract

Until the 1980s, coeliac disease was considered to be a rare disease, but in the 1990s it became clear that it was a frequent condition. Recently, it was suggested to affect 1 out of 100 subjects in the Western world. To understand what the true prevalence of coeliac disease is in the general population, we conducted a systematic review of published papers. The overall prevalence of coeliac disease in the general population appears to be around 1/160 (6.2‰), but this figure varies widely according to the diagnostic criteria used in the original papers. Prevalence obtained with tissue transglutaminase antibodies only was markedly higher than that obtained through a histological diagnosis. We conclude that the prevalence of coeliac disease in the general population has been over-estimated. This is mainly due to tissue transglutaminase antibodies being used as the only diagnostic tool.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalAnnals of Medicine
Volume42
Issue number8
DOIs
Publication statusPublished - Dec 2010

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Celiac Disease
Population
Western World
Antibodies
Rare Diseases
transglutaminase 2

Keywords

  • Coeliac disease
  • endomysial antibodies
  • epidemiology
  • tissue transglutaminase antibodies
  • villous atrophy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Are we not over-estimating the prevalence of coeliac disease in the general population? / Biagi, Federico; Klersy, Catherine; Balduzzi, Davide; Corazza, Gino Roberto.

In: Annals of Medicine, Vol. 42, No. 8, 12.2010, p. 557-561.

Research output: Contribution to journalArticle

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