ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments

ARIA Italia, Carlo Lombardi, Riccardo Asero, Diego Bagnasco, Francesco Blasi, Matteo Bonini, Mario Bussi, Rikki F. Canevari, Giorgio Walter Canonica, Paolo Castelnuovo, Lorenzo Cecchi, Lorenzo Cosmi, Matteo Gelardi, Enrico Heffler, Luciana Indinnimeo, Massimo Landi, Amelia Licari, Francesco Liotta, Alberto Macchi, Luca MalvezziGianluigi Marseglia, Claudio Micheletto, Antonino Musarra, Diego Peroni, Giorgio Piacentini, Venerino Poletti, Luca Richeldi, Angela Santoni, Michele Schiappoli, Gianenrico Senna, Adriano Vaghi, Alberto Villani, Giovanni Passalacqua

Research output: Contribution to journalArticlepeer-review


In the recent years, it was recognized that type-2 inflammation links many forms of nasal polyposis with severe asthma. Thus, some biological drugs developed for severe asthma appeared to exert an effect on nasal polyposis. So far, there are several trials supporting this concept; therefore, some monoclonal antibodies for severe asthma were assessed also in polyposis, with promising results. Since different specialists are involved in the management of nasal polyposis (eg, pulmonologists, ENT, allergists), it was felt that an educational and informative document was needed to better identify the indications of biologicals in nasal polyposis. We collected the main Italian Scientific Societies, and prepared (under the Allergic Rhinitis and its Impact on Asthma, ARIA) a document endorsed by all Societies, to provide a provisional statement for the future use of monoclonal antibodies as a medical treatment for polyposis. It is the first nationwide endorsed document on this aspect. The current pathogenic knowledge and the experimental evidence are herein reviewed, and some suggestions for a correct prescription and follow-up are provided.

Original languageEnglish
Article number100592
JournalWorld Allergy Organization Journal
Issue number10
Publication statusPublished - Oct 2021


  • ARIA
  • Biological antibodies
  • CRSwNP
  • Nasal polyps
  • Personalized medicine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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