ARNTL2 and SERPINE1: Potential biomarkers for tumor aggressiveness in colorectal cancer

Gianluigi Mazzoccoli; Valerio Pazienza; Anna Panza; Maria Rosa Valvano; Giorgia Benegiamo; Manlio Vinciguerra; Angelo Andriulli; Ada Piepoli

doi:10.1007/s00432-011-1126-6

ARNTL2 and SERPINE1: Potential biomarkers for tumor aggressiveness in colorectal cancer

Gianluigi Mazzoccoli, Valerio Pazienza, Anna Panza, Maria Rosa Valvano, Giorgia Benegiamo, Manlio Vinciguerra, Angelo Andriulli, Ada Piepoli

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Cathepsin and plasmin may favor cancer cell invasion degrading extracellular matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor type-1 (PAI-1). ARNTL2 activates the promoters of the PAI-1 gene, officially called SERPINE1, driving the circadian variation in circulating PAI-1 levels. Methods: We evaluated ARNTL2 and SERPINE1 expression in 50 colorectal cancer specimens and adjacent normal tissue and in colon cancer cell lines. Results: We found up-regulation of ARNTL2 (P = 0.004) and SERPINE1 (P = 0.002) in tumor tissue. A statistically significant association was found between high ARNTL2 mRNA levels and vascular invasion (P

Original language	English
Pages (from-to)	501-511
Number of pages	11
Journal	Journal of Cancer Research and Clinical Oncology
Volume	138
Issue number	3
DOIs	https://doi.org/10.1007/s00432-011-1126-6
Publication status	Published - Mar 2012

Keywords

ARNTL2
Colorectal cancer
SERPINE1

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1007/s00432-011-1126-6

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ARNTL2 and SERPINE1 : Potential biomarkers for tumor aggressiveness in colorectal cancer. / Mazzoccoli, Gianluigi ; Pazienza, Valerio ; Panza, Anna; Valvano, Maria Rosa; Benegiamo, Giorgia; Vinciguerra, Manlio; Andriulli, Angelo; Piepoli, Ada.

In: Journal of Cancer Research and Clinical Oncology, Vol. 138, No. 3, 03.2012, p. 501-511.

Research output: Contribution to journal › Article › peer-review

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AU - Mazzoccoli, Gianluigi

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AU - Panza, Anna

AU - Valvano, Maria Rosa

AU - Benegiamo, Giorgia

AU - Vinciguerra, Manlio

AU - Andriulli, Angelo

AU - Piepoli, Ada

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