ARNTL2 and SERPINE1: Potential biomarkers for tumor aggressiveness in colorectal cancer

Gianluigi Mazzoccoli, Valerio Pazienza, Anna Panza, Maria Rosa Valvano, Giorgia Benegiamo, Manlio Vinciguerra, Angelo Andriulli, Ada Piepoli

Research output: Contribution to journalArticlepeer-review


Purpose: Cathepsin and plasmin may favor cancer cell invasion degrading extracellular matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor type-1 (PAI-1). ARNTL2 activates the promoters of the PAI-1 gene, officially called SERPINE1, driving the circadian variation in circulating PAI-1 levels. Methods: We evaluated ARNTL2 and SERPINE1 expression in 50 colorectal cancer specimens and adjacent normal tissue and in colon cancer cell lines. Results: We found up-regulation of ARNTL2 (P = 0.004) and SERPINE1 (P = 0.002) in tumor tissue. A statistically significant association was found between high ARNTL2 mRNA levels and vascular invasion (P

Original languageEnglish
Pages (from-to)501-511
Number of pages11
JournalJournal of Cancer Research and Clinical Oncology
Issue number3
Publication statusPublished - Mar 2012


  • ARNTL2
  • Colorectal cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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