TERAPIA DELLE ARITMIE INDOTTE DA ISCHEMIA MIOCARDICA. ASSOCIAZIONE DI L-CARNITINA E PROPAFENONE E MEXILETINA

Translated title of the contribution: Arrhythmias and myocardial ischemia: Effect of L-carnitine in association with propafenone or mexiletine

S. Mondillo, S. Faglia, N. D'Aprile, L. Mangiacotti, M. A. Campolo, E. Agricola, V. Palazzuoli

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the antiarrhythmic effect of L-carnitine, propafenone and mexiletine, we tested the drugs in 50 patients with effort angina and ventricular ectopic beats (VEB). The patients were randomized in 5 groups: Group A: was treated with oral L-carnitine at the dose of 2 g x 3 for two weeks. Group B: oral propafenone at the dose of 300 mg x 3 for two weeks. Group C: as group B + L-carnitine + g x 3 at the second weeks. Group D: oral mexiletine at the dose of 200 mg x 3 for two weeks. Group E: as group D + L-carnitine 2 gr x 3 at the second week. After 7 and 14 days of treatment, in all patients an Holter examination was performed. Our results show that L-carnitine exerts a significant reduction of the VEB and its administration potentiates the antiarrhythmic effect of propafenone and mexiletine.

Translated title of the contributionArrhythmias and myocardial ischemia: Effect of L-carnitine in association with propafenone or mexiletine
Original languageItalian
Pages (from-to)769-774
Number of pages6
JournalClinica Terapeutica
Volume146
Issue number12
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Medicine(all)

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