Arrhythmogenic Cardiomyopathy: the Guilty Party in Adipogenesis

Ilaria Stadiotti; Valentina Catto; Michela Casella; Claudio Tondo; Giulio Pompilio; Elena Sommariva

doi:10.1007/s12265-017-9767-8

Arrhythmogenic Cardiomyopathy: the Guilty Party in Adipogenesis

Ilaria Stadiotti, Valentina Catto, Michela Casella, Claudio Tondo, Giulio Pompilio, Elena Sommariva

Centro Cardiologico Monzino

Research output: Contribution to journal › Review article › peer-review

Abstract

Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiac condition characterized by the replacement of the ventricular myocardium with fibro-fatty tissue, by arrhythmias and sudden death. Adipogenesis in ACM is considered an aberrant remodeling following myocardial loss. Which cell type(s) is (are) responsible for the adipose replacement is still matter of debate. A systematic overview of the different cells that have been, over time, considered as main players in adipose replacement is provided. The comprehension of the cellular component giving rise to arrhythmogenic cardiomyopathy substrate defects may represent both an essential tool for mechanistic studies of disease pathogenesis and a novel possible therapeutic target.

Original language	English
Pages (from-to)	446-454
Number of pages	9
Journal	Journal of Cardiovascular Translational Research
Volume	10
Issue number	5-6
DOIs	https://doi.org/10.1007/s12265-017-9767-8
Publication status	Published - Dec 1 2017

Keywords

Adipogenesis
Arrhythmogenic cardiomyopathy
ARVC
Cardiomyocytes
Mesenchymal cells
Progenitors

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmaceutical Science
Cardiology and Cardiovascular Medicine
Genetics(clinical)

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10.1007/s12265-017-9767-8

Cite this

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abstract = "Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiac condition characterized by the replacement of the ventricular myocardium with fibro-fatty tissue, by arrhythmias and sudden death. Adipogenesis in ACM is considered an aberrant remodeling following myocardial loss. Which cell type(s) is (are) responsible for the adipose replacement is still matter of debate. A systematic overview of the different cells that have been, over time, considered as main players in adipose replacement is provided. The comprehension of the cellular component giving rise to arrhythmogenic cardiomyopathy substrate defects may represent both an essential tool for mechanistic studies of disease pathogenesis and a novel possible therapeutic target.",

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T2 - the Guilty Party in Adipogenesis

AU - Stadiotti, Ilaria

AU - Catto, Valentina

AU - Casella, Michela

AU - Tondo, Claudio

AU - Pompilio, Giulio

AU - Sommariva, Elena

PY - 2017/12/1

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N2 - Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiac condition characterized by the replacement of the ventricular myocardium with fibro-fatty tissue, by arrhythmias and sudden death. Adipogenesis in ACM is considered an aberrant remodeling following myocardial loss. Which cell type(s) is (are) responsible for the adipose replacement is still matter of debate. A systematic overview of the different cells that have been, over time, considered as main players in adipose replacement is provided. The comprehension of the cellular component giving rise to arrhythmogenic cardiomyopathy substrate defects may represent both an essential tool for mechanistic studies of disease pathogenesis and a novel possible therapeutic target.

AB - Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiac condition characterized by the replacement of the ventricular myocardium with fibro-fatty tissue, by arrhythmias and sudden death. Adipogenesis in ACM is considered an aberrant remodeling following myocardial loss. Which cell type(s) is (are) responsible for the adipose replacement is still matter of debate. A systematic overview of the different cells that have been, over time, considered as main players in adipose replacement is provided. The comprehension of the cellular component giving rise to arrhythmogenic cardiomyopathy substrate defects may represent both an essential tool for mechanistic studies of disease pathogenesis and a novel possible therapeutic target.

KW - Adipogenesis

KW - Arrhythmogenic cardiomyopathy

KW - ARVC

KW - Cardiomyocytes

KW - Mesenchymal cells

KW - Progenitors

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Arrhythmogenic Cardiomyopathy: the Guilty Party in Adipogenesis

Abstract

Keywords

ASJC Scopus subject areas

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