Abstract
Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiac condition characterized by the replacement of the ventricular myocardium with fibro-fatty tissue, by arrhythmias and sudden death. Adipogenesis in ACM is considered an aberrant remodeling following myocardial loss. Which cell type(s) is (are) responsible for the adipose replacement is still matter of debate. A systematic overview of the different cells that have been, over time, considered as main players in adipose replacement is provided. The comprehension of the cellular component giving rise to arrhythmogenic cardiomyopathy substrate defects may represent both an essential tool for mechanistic studies of disease pathogenesis and a novel possible therapeutic target.
Original language | English |
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Pages (from-to) | 446-454 |
Number of pages | 9 |
Journal | Journal of Cardiovascular Translational Research |
Volume | 10 |
Issue number | 5-6 |
DOIs | |
Publication status | Published - Dec 1 2017 |
Keywords
- Adipogenesis
- Arrhythmogenic cardiomyopathy
- ARVC
- Cardiomyocytes
- Mesenchymal cells
- Progenitors
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Pharmaceutical Science
- Cardiology and Cardiovascular Medicine
- Genetics(clinical)