Arrhythmogenic Cardiomyopathy: the Guilty Party in Adipogenesis

Research output: Contribution to journalReview articlepeer-review

Abstract

Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiac condition characterized by the replacement of the ventricular myocardium with fibro-fatty tissue, by arrhythmias and sudden death. Adipogenesis in ACM is considered an aberrant remodeling following myocardial loss. Which cell type(s) is (are) responsible for the adipose replacement is still matter of debate. A systematic overview of the different cells that have been, over time, considered as main players in adipose replacement is provided. The comprehension of the cellular component giving rise to arrhythmogenic cardiomyopathy substrate defects may represent both an essential tool for mechanistic studies of disease pathogenesis and a novel possible therapeutic target.

Original languageEnglish
Pages (from-to)446-454
Number of pages9
JournalJournal of Cardiovascular Translational Research
Volume10
Issue number5-6
DOIs
Publication statusPublished - Dec 1 2017

Keywords

  • Adipogenesis
  • Arrhythmogenic cardiomyopathy
  • ARVC
  • Cardiomyocytes
  • Mesenchymal cells
  • Progenitors

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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