ART in Europe, 2014: Results generated from European registries by ESHRE

Christian De Geyter, Carlos Calhaz-Jorge, M. S. Kupka, Christine Wyns, Edgar Mocanu, T. Motrenko, Giulia Scaravelli, J. Smeenk, S. Vidakovic, V. Goossens, Orion Gliozheni, Heinz Strohmer, Elena Petrovskaya, Oleg Tishkevich, Kris Bogaerts, Devleta Balic, Sanja Sibincic, Irena Antonova, Hrvoje Vrcic, Dejan LjiljakMichael Pelekanos, Karel Rezabek, Mgr Jitka Markova, Josephine Lemmen, Deniss Sõritsa, Mika Gissler, Aila Tiitinen, Dominique Royere, Andreas Tandler—schneider, Markus Kimmel, Aris J. Antsaklis, Dimitris Loutradis, Janos Urbancsek, G. Kosztolanyi, Hilmar Bjorgvinsson, Roberto de Luca, Vyacheslav Lokshin, Valiyev Ravil, Valeria Magomedova, Zivile Gudleviciene, Giedre Belo Lopes, Zoranco Petanovski, Jean Calleja-Agius, Josephine Xuereb, Veaceslav Moshin, Tatjana Motrenko Simic, Dragana Vukicevic, Liv Bente Romundstad, Anna Janicka, Ana Rita Laranjeira

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

STUDY QUESTION: What are the European trends and developments in ART and IUI in 2014 as compared to previous years? SUMMARY ANSWER: The 18th ESHRE report on ART shows a continuing expansion of both treatment numbers in Europe and more variability in treatment modalities resulting in a rising contribution to the birth rates in most participating countries. WHAT IS KNOWN ALREADY: Since 1997, ART data generated by national registries have been collected, analysed by the European IVF-monitoring (EIM) Consortium and reported in 17 manuscripts published in Human Reproduction. STUDY DESIGN, SIZE, DURATION: Continuous collection of European data by the EIM for ESHRE. The data for treatments performed in 2014 between 1 January and 31 December in 39 European countries were provided by national registries or on a voluntary basis by clinics or professional societies. PARTICIPANTS/MATERIALS, SETTING, METHODS: From 39 countries and 1279 institutions offering ART services, a total of 776 556 treatment cycles, involving 146 148 with IVF, 362 285 with ICSI, 192 027 with frozen embryo replacement (FER), 15 894 with PGT, 56 516 with egg donation (ED), 292 with IVM and 3404 with frozen oocyte replacement (FOR) were reported. European data on IUI using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1364 institutions offering IUI in 26 countries and 21 countries, respectively. A total of 120 789 treatments with IUI-H and 49 163 treatments with IUI-D were included. MAIN RESULTS AND THE ROLE OF CHANCE: In 14 countries (17 in 2013), where all institutions contributed to their respective national registers, a total of 291 235 treatment cycles were performed in a population of ~208 million inhabitants, corresponding to 1925 cycles per million inhabitants (range: 423-2978 per million inhabitants). After treatment with IVF the clinical pregnancy rates (PR) per aspiration and per transfer were marginally higher in 2014 than in 2013, at 29.9 and 35.8% versus 29.6 and 34.5%, respectively. After treatment with ICSI the PR per aspiration and per transfer were also higher than those achieved in 2013 (28.4 and 35.0% versus 27.8 and 32.9%, respectively). After FER with own embryos the PR continued to rise, from 27.0% in 2013 to 27.6% in 2014. After ED a similar trend was observed with PR reaching 50.3% per fresh transfer (49.8% in 2013) and 48.7% for FOR (46.4% in 2013). The delivery rates (DR) after IUIremained stable at 8.5% after IUI-H (8.6% in 2013) and at 11.6% after IUI-D (11.1% in 2013). In IVF and ICSI together, 1, 2, 3 and ≥4 embryos were transferred in 34.9, 54.5, 9.9 and in 0.7% of all treatments, respectively (corresponding to 31.4%, 56.3, 11.5% and 1% in 2013). This evolution in embryo transfer strategy in both IVF and ICSI resulted in a singleton, twin and triplet DR of 82.5, 17.0 and 0.5%, respectively (compared to 82.0, 17.5 and 0.5%, respectively, in 2013). Treatments with FER in 2014 resulted in a twin and triplet DR of 12.4 and 0.3%, respectively (versus 12.5 and 0.3% in 2013). Twin and triplet DR after IUI were 9.5 and 0.3%, respectively, after IUI-H (in 2013:9.5 and 0.6%) and 7.7 and 0.3% after IUI-D (in 2013: 7.5 and 0.3%). LIMITATION, REASONS FOR CAUTION: The method of data collection and reporting varies among European countries. The EIM receives aggregated data from various countries with variable levels of completeness. Registries from a number of countries have failed to provide adequate data about the number of initiated cycles and deliveries. As long as incomplete data are provided, the results should be interpreted with caution. WIDER IMPLICATIONS OF THE FINDINGS: The 18th ESHRE report on ART shows a continuing expansion of treatment numbers in Europe. The number of treatments reported, the variability in treatment modalities and the rising contribution to the birth rates in most participating countries point towards the increasing impact of ART on reproduction in Europe. Being the largest data collection on ART, the report gives detailed information about ongoing developments in the field.

Original languageEnglish
Pages (from-to)1586-1601
Number of pages16
JournalHuman Reproduction
Volume33
Issue number9
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Registries
Intracytoplasmic Sperm Injections
Pregnancy Rate
Semen
Spouses
Embryonic Structures
Therapeutics
Tissue Donors
Oocytes
Birth Rate
Reproduction
Ovum
Manuscripts
Embryo Transfer
Research Design

Keywords

  • egg donation
  • frozen embryo replacement
  • ICSI
  • insemination
  • IUI using donor semen
  • IUI using partner's semen
  • IVF
  • registry
  • surveillance
  • vigilance

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

De Geyter, C., Calhaz-Jorge, C., Kupka, M. S., Wyns, C., Mocanu, E., Motrenko, T., ... Laranjeira, A. R. (2018). ART in Europe, 2014: Results generated from European registries by ESHRE. Human Reproduction, 33(9), 1586-1601. https://doi.org/10.1093/humrep/dey242

ART in Europe, 2014 : Results generated from European registries by ESHRE. / De Geyter, Christian; Calhaz-Jorge, Carlos; Kupka, M. S.; Wyns, Christine; Mocanu, Edgar; Motrenko, T.; Scaravelli, Giulia; Smeenk, J.; Vidakovic, S.; Goossens, V.; Gliozheni, Orion; Strohmer, Heinz; Petrovskaya, Elena; Tishkevich, Oleg; Bogaerts, Kris; Balic, Devleta; Sibincic, Sanja; Antonova, Irena; Vrcic, Hrvoje; Ljiljak, Dejan; Pelekanos, Michael; Rezabek, Karel; Markova, Mgr Jitka; Lemmen, Josephine; Sõritsa, Deniss; Gissler, Mika; Tiitinen, Aila; Royere, Dominique; Tandler—schneider, Andreas; Kimmel, Markus; Antsaklis, Aris J.; Loutradis, Dimitris; Urbancsek, Janos; Kosztolanyi, G.; Bjorgvinsson, Hilmar; de Luca, Roberto; Lokshin, Vyacheslav; Ravil, Valiyev; Magomedova, Valeria; Gudleviciene, Zivile; Belo Lopes, Giedre; Petanovski, Zoranco; Calleja-Agius, Jean; Xuereb, Josephine; Moshin, Veaceslav; Simic, Tatjana Motrenko; Vukicevic, Dragana; Romundstad, Liv Bente; Janicka, Anna; Laranjeira, Ana Rita.

In: Human Reproduction, Vol. 33, No. 9, 01.01.2018, p. 1586-1601.

Research output: Contribution to journalArticle

De Geyter, C, Calhaz-Jorge, C, Kupka, MS, Wyns, C, Mocanu, E, Motrenko, T, Scaravelli, G, Smeenk, J, Vidakovic, S, Goossens, V, Gliozheni, O, Strohmer, H, Petrovskaya, E, Tishkevich, O, Bogaerts, K, Balic, D, Sibincic, S, Antonova, I, Vrcic, H, Ljiljak, D, Pelekanos, M, Rezabek, K, Markova, MJ, Lemmen, J, Sõritsa, D, Gissler, M, Tiitinen, A, Royere, D, Tandler—schneider, A, Kimmel, M, Antsaklis, AJ, Loutradis, D, Urbancsek, J, Kosztolanyi, G, Bjorgvinsson, H, de Luca, R, Lokshin, V, Ravil, V, Magomedova, V, Gudleviciene, Z, Belo Lopes, G, Petanovski, Z, Calleja-Agius, J, Xuereb, J, Moshin, V, Simic, TM, Vukicevic, D, Romundstad, LB, Janicka, A & Laranjeira, AR 2018, 'ART in Europe, 2014: Results generated from European registries by ESHRE', Human Reproduction, vol. 33, no. 9, pp. 1586-1601. https://doi.org/10.1093/humrep/dey242
De Geyter C, Calhaz-Jorge C, Kupka MS, Wyns C, Mocanu E, Motrenko T et al. ART in Europe, 2014: Results generated from European registries by ESHRE. Human Reproduction. 2018 Jan 1;33(9):1586-1601. https://doi.org/10.1093/humrep/dey242
De Geyter, Christian ; Calhaz-Jorge, Carlos ; Kupka, M. S. ; Wyns, Christine ; Mocanu, Edgar ; Motrenko, T. ; Scaravelli, Giulia ; Smeenk, J. ; Vidakovic, S. ; Goossens, V. ; Gliozheni, Orion ; Strohmer, Heinz ; Petrovskaya, Elena ; Tishkevich, Oleg ; Bogaerts, Kris ; Balic, Devleta ; Sibincic, Sanja ; Antonova, Irena ; Vrcic, Hrvoje ; Ljiljak, Dejan ; Pelekanos, Michael ; Rezabek, Karel ; Markova, Mgr Jitka ; Lemmen, Josephine ; Sõritsa, Deniss ; Gissler, Mika ; Tiitinen, Aila ; Royere, Dominique ; Tandler—schneider, Andreas ; Kimmel, Markus ; Antsaklis, Aris J. ; Loutradis, Dimitris ; Urbancsek, Janos ; Kosztolanyi, G. ; Bjorgvinsson, Hilmar ; de Luca, Roberto ; Lokshin, Vyacheslav ; Ravil, Valiyev ; Magomedova, Valeria ; Gudleviciene, Zivile ; Belo Lopes, Giedre ; Petanovski, Zoranco ; Calleja-Agius, Jean ; Xuereb, Josephine ; Moshin, Veaceslav ; Simic, Tatjana Motrenko ; Vukicevic, Dragana ; Romundstad, Liv Bente ; Janicka, Anna ; Laranjeira, Ana Rita. / ART in Europe, 2014 : Results generated from European registries by ESHRE. In: Human Reproduction. 2018 ; Vol. 33, No. 9. pp. 1586-1601.
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abstract = "STUDY QUESTION: What are the European trends and developments in ART and IUI in 2014 as compared to previous years? SUMMARY ANSWER: The 18th ESHRE report on ART shows a continuing expansion of both treatment numbers in Europe and more variability in treatment modalities resulting in a rising contribution to the birth rates in most participating countries. WHAT IS KNOWN ALREADY: Since 1997, ART data generated by national registries have been collected, analysed by the European IVF-monitoring (EIM) Consortium and reported in 17 manuscripts published in Human Reproduction. STUDY DESIGN, SIZE, DURATION: Continuous collection of European data by the EIM for ESHRE. The data for treatments performed in 2014 between 1 January and 31 December in 39 European countries were provided by national registries or on a voluntary basis by clinics or professional societies. PARTICIPANTS/MATERIALS, SETTING, METHODS: From 39 countries and 1279 institutions offering ART services, a total of 776 556 treatment cycles, involving 146 148 with IVF, 362 285 with ICSI, 192 027 with frozen embryo replacement (FER), 15 894 with PGT, 56 516 with egg donation (ED), 292 with IVM and 3404 with frozen oocyte replacement (FOR) were reported. European data on IUI using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1364 institutions offering IUI in 26 countries and 21 countries, respectively. A total of 120 789 treatments with IUI-H and 49 163 treatments with IUI-D were included. MAIN RESULTS AND THE ROLE OF CHANCE: In 14 countries (17 in 2013), where all institutions contributed to their respective national registers, a total of 291 235 treatment cycles were performed in a population of ~208 million inhabitants, corresponding to 1925 cycles per million inhabitants (range: 423-2978 per million inhabitants). After treatment with IVF the clinical pregnancy rates (PR) per aspiration and per transfer were marginally higher in 2014 than in 2013, at 29.9 and 35.8{\%} versus 29.6 and 34.5{\%}, respectively. After treatment with ICSI the PR per aspiration and per transfer were also higher than those achieved in 2013 (28.4 and 35.0{\%} versus 27.8 and 32.9{\%}, respectively). After FER with own embryos the PR continued to rise, from 27.0{\%} in 2013 to 27.6{\%} in 2014. After ED a similar trend was observed with PR reaching 50.3{\%} per fresh transfer (49.8{\%} in 2013) and 48.7{\%} for FOR (46.4{\%} in 2013). The delivery rates (DR) after IUIremained stable at 8.5{\%} after IUI-H (8.6{\%} in 2013) and at 11.6{\%} after IUI-D (11.1{\%} in 2013). In IVF and ICSI together, 1, 2, 3 and ≥4 embryos were transferred in 34.9, 54.5, 9.9 and in 0.7{\%} of all treatments, respectively (corresponding to 31.4{\%}, 56.3, 11.5{\%} and 1{\%} in 2013). This evolution in embryo transfer strategy in both IVF and ICSI resulted in a singleton, twin and triplet DR of 82.5, 17.0 and 0.5{\%}, respectively (compared to 82.0, 17.5 and 0.5{\%}, respectively, in 2013). Treatments with FER in 2014 resulted in a twin and triplet DR of 12.4 and 0.3{\%}, respectively (versus 12.5 and 0.3{\%} in 2013). Twin and triplet DR after IUI were 9.5 and 0.3{\%}, respectively, after IUI-H (in 2013:9.5 and 0.6{\%}) and 7.7 and 0.3{\%} after IUI-D (in 2013: 7.5 and 0.3{\%}). LIMITATION, REASONS FOR CAUTION: The method of data collection and reporting varies among European countries. The EIM receives aggregated data from various countries with variable levels of completeness. Registries from a number of countries have failed to provide adequate data about the number of initiated cycles and deliveries. As long as incomplete data are provided, the results should be interpreted with caution. WIDER IMPLICATIONS OF THE FINDINGS: The 18th ESHRE report on ART shows a continuing expansion of treatment numbers in Europe. The number of treatments reported, the variability in treatment modalities and the rising contribution to the birth rates in most participating countries point towards the increasing impact of ART on reproduction in Europe. Being the largest data collection on ART, the report gives detailed information about ongoing developments in the field.",
keywords = "egg donation, frozen embryo replacement, ICSI, insemination, IUI using donor semen, IUI using partner's semen, IVF, registry, surveillance, vigilance",
author = "{De Geyter}, Christian and Carlos Calhaz-Jorge and Kupka, {M. S.} and Christine Wyns and Edgar Mocanu and T. Motrenko and Giulia Scaravelli and J. Smeenk and S. Vidakovic and V. Goossens and Orion Gliozheni and Heinz Strohmer and Elena Petrovskaya and Oleg Tishkevich and Kris Bogaerts and Devleta Balic and Sanja Sibincic and Irena Antonova and Hrvoje Vrcic and Dejan Ljiljak and Michael Pelekanos and Karel Rezabek and Markova, {Mgr Jitka} and Josephine Lemmen and Deniss S{\~o}ritsa and Mika Gissler and Aila Tiitinen and Dominique Royere and Andreas Tandler—schneider and Markus Kimmel and Antsaklis, {Aris J.} and Dimitris Loutradis and Janos Urbancsek and G. Kosztolanyi and Hilmar Bjorgvinsson and {de Luca}, Roberto and Vyacheslav Lokshin and Valiyev Ravil and Valeria Magomedova and Zivile Gudleviciene and {Belo Lopes}, Giedre and Zoranco Petanovski and Jean Calleja-Agius and Josephine Xuereb and Veaceslav Moshin and Simic, {Tatjana Motrenko} and Dragana Vukicevic and Romundstad, {Liv Bente} and Anna Janicka and Laranjeira, {Ana Rita}",
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month = "1",
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journal = "Human Reproduction",
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TY - JOUR

T1 - ART in Europe, 2014

T2 - Results generated from European registries by ESHRE

AU - De Geyter, Christian

AU - Calhaz-Jorge, Carlos

AU - Kupka, M. S.

AU - Wyns, Christine

AU - Mocanu, Edgar

AU - Motrenko, T.

AU - Scaravelli, Giulia

AU - Smeenk, J.

AU - Vidakovic, S.

AU - Goossens, V.

AU - Gliozheni, Orion

AU - Strohmer, Heinz

AU - Petrovskaya, Elena

AU - Tishkevich, Oleg

AU - Bogaerts, Kris

AU - Balic, Devleta

AU - Sibincic, Sanja

AU - Antonova, Irena

AU - Vrcic, Hrvoje

AU - Ljiljak, Dejan

AU - Pelekanos, Michael

AU - Rezabek, Karel

AU - Markova, Mgr Jitka

AU - Lemmen, Josephine

AU - Sõritsa, Deniss

AU - Gissler, Mika

AU - Tiitinen, Aila

AU - Royere, Dominique

AU - Tandler—schneider, Andreas

AU - Kimmel, Markus

AU - Antsaklis, Aris J.

AU - Loutradis, Dimitris

AU - Urbancsek, Janos

AU - Kosztolanyi, G.

AU - Bjorgvinsson, Hilmar

AU - de Luca, Roberto

AU - Lokshin, Vyacheslav

AU - Ravil, Valiyev

AU - Magomedova, Valeria

AU - Gudleviciene, Zivile

AU - Belo Lopes, Giedre

AU - Petanovski, Zoranco

AU - Calleja-Agius, Jean

AU - Xuereb, Josephine

AU - Moshin, Veaceslav

AU - Simic, Tatjana Motrenko

AU - Vukicevic, Dragana

AU - Romundstad, Liv Bente

AU - Janicka, Anna

AU - Laranjeira, Ana Rita

PY - 2018/1/1

Y1 - 2018/1/1

N2 - STUDY QUESTION: What are the European trends and developments in ART and IUI in 2014 as compared to previous years? SUMMARY ANSWER: The 18th ESHRE report on ART shows a continuing expansion of both treatment numbers in Europe and more variability in treatment modalities resulting in a rising contribution to the birth rates in most participating countries. WHAT IS KNOWN ALREADY: Since 1997, ART data generated by national registries have been collected, analysed by the European IVF-monitoring (EIM) Consortium and reported in 17 manuscripts published in Human Reproduction. STUDY DESIGN, SIZE, DURATION: Continuous collection of European data by the EIM for ESHRE. The data for treatments performed in 2014 between 1 January and 31 December in 39 European countries were provided by national registries or on a voluntary basis by clinics or professional societies. PARTICIPANTS/MATERIALS, SETTING, METHODS: From 39 countries and 1279 institutions offering ART services, a total of 776 556 treatment cycles, involving 146 148 with IVF, 362 285 with ICSI, 192 027 with frozen embryo replacement (FER), 15 894 with PGT, 56 516 with egg donation (ED), 292 with IVM and 3404 with frozen oocyte replacement (FOR) were reported. European data on IUI using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1364 institutions offering IUI in 26 countries and 21 countries, respectively. A total of 120 789 treatments with IUI-H and 49 163 treatments with IUI-D were included. MAIN RESULTS AND THE ROLE OF CHANCE: In 14 countries (17 in 2013), where all institutions contributed to their respective national registers, a total of 291 235 treatment cycles were performed in a population of ~208 million inhabitants, corresponding to 1925 cycles per million inhabitants (range: 423-2978 per million inhabitants). After treatment with IVF the clinical pregnancy rates (PR) per aspiration and per transfer were marginally higher in 2014 than in 2013, at 29.9 and 35.8% versus 29.6 and 34.5%, respectively. After treatment with ICSI the PR per aspiration and per transfer were also higher than those achieved in 2013 (28.4 and 35.0% versus 27.8 and 32.9%, respectively). After FER with own embryos the PR continued to rise, from 27.0% in 2013 to 27.6% in 2014. After ED a similar trend was observed with PR reaching 50.3% per fresh transfer (49.8% in 2013) and 48.7% for FOR (46.4% in 2013). The delivery rates (DR) after IUIremained stable at 8.5% after IUI-H (8.6% in 2013) and at 11.6% after IUI-D (11.1% in 2013). In IVF and ICSI together, 1, 2, 3 and ≥4 embryos were transferred in 34.9, 54.5, 9.9 and in 0.7% of all treatments, respectively (corresponding to 31.4%, 56.3, 11.5% and 1% in 2013). This evolution in embryo transfer strategy in both IVF and ICSI resulted in a singleton, twin and triplet DR of 82.5, 17.0 and 0.5%, respectively (compared to 82.0, 17.5 and 0.5%, respectively, in 2013). Treatments with FER in 2014 resulted in a twin and triplet DR of 12.4 and 0.3%, respectively (versus 12.5 and 0.3% in 2013). Twin and triplet DR after IUI were 9.5 and 0.3%, respectively, after IUI-H (in 2013:9.5 and 0.6%) and 7.7 and 0.3% after IUI-D (in 2013: 7.5 and 0.3%). LIMITATION, REASONS FOR CAUTION: The method of data collection and reporting varies among European countries. The EIM receives aggregated data from various countries with variable levels of completeness. Registries from a number of countries have failed to provide adequate data about the number of initiated cycles and deliveries. As long as incomplete data are provided, the results should be interpreted with caution. WIDER IMPLICATIONS OF THE FINDINGS: The 18th ESHRE report on ART shows a continuing expansion of treatment numbers in Europe. The number of treatments reported, the variability in treatment modalities and the rising contribution to the birth rates in most participating countries point towards the increasing impact of ART on reproduction in Europe. Being the largest data collection on ART, the report gives detailed information about ongoing developments in the field.

AB - STUDY QUESTION: What are the European trends and developments in ART and IUI in 2014 as compared to previous years? SUMMARY ANSWER: The 18th ESHRE report on ART shows a continuing expansion of both treatment numbers in Europe and more variability in treatment modalities resulting in a rising contribution to the birth rates in most participating countries. WHAT IS KNOWN ALREADY: Since 1997, ART data generated by national registries have been collected, analysed by the European IVF-monitoring (EIM) Consortium and reported in 17 manuscripts published in Human Reproduction. STUDY DESIGN, SIZE, DURATION: Continuous collection of European data by the EIM for ESHRE. The data for treatments performed in 2014 between 1 January and 31 December in 39 European countries were provided by national registries or on a voluntary basis by clinics or professional societies. PARTICIPANTS/MATERIALS, SETTING, METHODS: From 39 countries and 1279 institutions offering ART services, a total of 776 556 treatment cycles, involving 146 148 with IVF, 362 285 with ICSI, 192 027 with frozen embryo replacement (FER), 15 894 with PGT, 56 516 with egg donation (ED), 292 with IVM and 3404 with frozen oocyte replacement (FOR) were reported. European data on IUI using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1364 institutions offering IUI in 26 countries and 21 countries, respectively. A total of 120 789 treatments with IUI-H and 49 163 treatments with IUI-D were included. MAIN RESULTS AND THE ROLE OF CHANCE: In 14 countries (17 in 2013), where all institutions contributed to their respective national registers, a total of 291 235 treatment cycles were performed in a population of ~208 million inhabitants, corresponding to 1925 cycles per million inhabitants (range: 423-2978 per million inhabitants). After treatment with IVF the clinical pregnancy rates (PR) per aspiration and per transfer were marginally higher in 2014 than in 2013, at 29.9 and 35.8% versus 29.6 and 34.5%, respectively. After treatment with ICSI the PR per aspiration and per transfer were also higher than those achieved in 2013 (28.4 and 35.0% versus 27.8 and 32.9%, respectively). After FER with own embryos the PR continued to rise, from 27.0% in 2013 to 27.6% in 2014. After ED a similar trend was observed with PR reaching 50.3% per fresh transfer (49.8% in 2013) and 48.7% for FOR (46.4% in 2013). The delivery rates (DR) after IUIremained stable at 8.5% after IUI-H (8.6% in 2013) and at 11.6% after IUI-D (11.1% in 2013). In IVF and ICSI together, 1, 2, 3 and ≥4 embryos were transferred in 34.9, 54.5, 9.9 and in 0.7% of all treatments, respectively (corresponding to 31.4%, 56.3, 11.5% and 1% in 2013). This evolution in embryo transfer strategy in both IVF and ICSI resulted in a singleton, twin and triplet DR of 82.5, 17.0 and 0.5%, respectively (compared to 82.0, 17.5 and 0.5%, respectively, in 2013). Treatments with FER in 2014 resulted in a twin and triplet DR of 12.4 and 0.3%, respectively (versus 12.5 and 0.3% in 2013). Twin and triplet DR after IUI were 9.5 and 0.3%, respectively, after IUI-H (in 2013:9.5 and 0.6%) and 7.7 and 0.3% after IUI-D (in 2013: 7.5 and 0.3%). LIMITATION, REASONS FOR CAUTION: The method of data collection and reporting varies among European countries. The EIM receives aggregated data from various countries with variable levels of completeness. Registries from a number of countries have failed to provide adequate data about the number of initiated cycles and deliveries. As long as incomplete data are provided, the results should be interpreted with caution. WIDER IMPLICATIONS OF THE FINDINGS: The 18th ESHRE report on ART shows a continuing expansion of treatment numbers in Europe. The number of treatments reported, the variability in treatment modalities and the rising contribution to the birth rates in most participating countries point towards the increasing impact of ART on reproduction in Europe. Being the largest data collection on ART, the report gives detailed information about ongoing developments in the field.

KW - egg donation

KW - frozen embryo replacement

KW - ICSI

KW - insemination

KW - IUI using donor semen

KW - IUI using partner's semen

KW - IVF

KW - registry

KW - surveillance

KW - vigilance

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U2 - 10.1093/humrep/dey242

DO - 10.1093/humrep/dey242

M3 - Article

C2 - 30032255

AN - SCOPUS:85055001857

VL - 33

SP - 1586

EP - 1601

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 9

ER -