Utilizzo di omoinnesto arterioso in caso di infezione di protesi vascolare

Revisione della nostra esperienza alla luce di uno studio di compatibilità

Translated title of the contribution: Arterial allograft reconstruction in infected vascular prosthetic grafts: Review of our series in the light of a compatibility study

A. Odero, S. Pirrelli, V. Arici, G. Piccolo, A. Guarino, C. Klersy

Research output: Contribution to journalArticle

Abstract

Background. The use of arterial allograft is now a widespread therapeutic alternative in infected vascular prosthetic grafts and mycotic aneurysms. Our series is analysed in function of some factors possibly linked to the development of allograft-correlated complications. Methods. Between December 1994 and March 2002, 23 patients with infected vascular prosthetic graft were treated at the Vascular Surgery Clinic, University of Pavia, IRCCS San Matteo Polyclinic. The patients were subjected to surgical removal of the infected prosthetic graft and in situ revascularisation through homologous arterial graft. Mean follow-up was 27.2 month (range 40 days-77.4 months). Results. In 2 cases it was impossible to implant the allograft: 1 for intraoperative decease of the patient, 1 for intraoperative rupture of the allograft. Overall mortality was 34.7%; the amputation rate was 13%. In 34.6% of cases no microorganism was isolated on culturing the explanted prosthetic graft. The rate of perioperative allograft-correlated complications was 30.5%, with mean onset at 6 days. The rate of late allograft-correlated complications was 39%, with mean onset at 25.9 months. No significant association was found between AB0 compatibility and development of allograft-correlated complications. A significant association was detected between lower risk of developing early complications and age of donor above 40 years. Conclusions. Among factors influencing the development of allograft-correlated complications, age of donor below 40 years and history of drug allergies were found to be associated with a higher risk of allograft-correlated complications.

Original languageItalian
Pages (from-to)333-346
Number of pages14
JournalGiornale Italiano di Chirurgia Vascolare
Volume10
Issue number4
Publication statusPublished - Dec 2003

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Allografts
Blood Vessels
Transplants
Tissue Donors
Infected Aneurysm
Drug Hypersensitivity
Amputation
Rupture
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{a98c9387faf84153b1d0432b6788d0c1,
title = "Utilizzo di omoinnesto arterioso in caso di infezione di protesi vascolare: Revisione della nostra esperienza alla luce di uno studio di compatibilit{\`a}",
abstract = "Background. The use of arterial allograft is now a widespread therapeutic alternative in infected vascular prosthetic grafts and mycotic aneurysms. Our series is analysed in function of some factors possibly linked to the development of allograft-correlated complications. Methods. Between December 1994 and March 2002, 23 patients with infected vascular prosthetic graft were treated at the Vascular Surgery Clinic, University of Pavia, IRCCS San Matteo Polyclinic. The patients were subjected to surgical removal of the infected prosthetic graft and in situ revascularisation through homologous arterial graft. Mean follow-up was 27.2 month (range 40 days-77.4 months). Results. In 2 cases it was impossible to implant the allograft: 1 for intraoperative decease of the patient, 1 for intraoperative rupture of the allograft. Overall mortality was 34.7{\%}; the amputation rate was 13{\%}. In 34.6{\%} of cases no microorganism was isolated on culturing the explanted prosthetic graft. The rate of perioperative allograft-correlated complications was 30.5{\%}, with mean onset at 6 days. The rate of late allograft-correlated complications was 39{\%}, with mean onset at 25.9 months. No significant association was found between AB0 compatibility and development of allograft-correlated complications. A significant association was detected between lower risk of developing early complications and age of donor above 40 years. Conclusions. Among factors influencing the development of allograft-correlated complications, age of donor below 40 years and history of drug allergies were found to be associated with a higher risk of allograft-correlated complications.",
keywords = "Aneurysm, infected, Prosthesis related infections, Transplantation, homologous",
author = "A. Odero and S. Pirrelli and V. Arici and G. Piccolo and A. Guarino and C. Klersy",
year = "2003",
month = "12",
language = "Italian",
volume = "10",
pages = "333--346",
journal = "Giornale Italiano di Chirurgia Vascolare",
issn = "1122-8679",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "4",

}

TY - JOUR

T1 - Utilizzo di omoinnesto arterioso in caso di infezione di protesi vascolare

T2 - Revisione della nostra esperienza alla luce di uno studio di compatibilità

AU - Odero, A.

AU - Pirrelli, S.

AU - Arici, V.

AU - Piccolo, G.

AU - Guarino, A.

AU - Klersy, C.

PY - 2003/12

Y1 - 2003/12

N2 - Background. The use of arterial allograft is now a widespread therapeutic alternative in infected vascular prosthetic grafts and mycotic aneurysms. Our series is analysed in function of some factors possibly linked to the development of allograft-correlated complications. Methods. Between December 1994 and March 2002, 23 patients with infected vascular prosthetic graft were treated at the Vascular Surgery Clinic, University of Pavia, IRCCS San Matteo Polyclinic. The patients were subjected to surgical removal of the infected prosthetic graft and in situ revascularisation through homologous arterial graft. Mean follow-up was 27.2 month (range 40 days-77.4 months). Results. In 2 cases it was impossible to implant the allograft: 1 for intraoperative decease of the patient, 1 for intraoperative rupture of the allograft. Overall mortality was 34.7%; the amputation rate was 13%. In 34.6% of cases no microorganism was isolated on culturing the explanted prosthetic graft. The rate of perioperative allograft-correlated complications was 30.5%, with mean onset at 6 days. The rate of late allograft-correlated complications was 39%, with mean onset at 25.9 months. No significant association was found between AB0 compatibility and development of allograft-correlated complications. A significant association was detected between lower risk of developing early complications and age of donor above 40 years. Conclusions. Among factors influencing the development of allograft-correlated complications, age of donor below 40 years and history of drug allergies were found to be associated with a higher risk of allograft-correlated complications.

AB - Background. The use of arterial allograft is now a widespread therapeutic alternative in infected vascular prosthetic grafts and mycotic aneurysms. Our series is analysed in function of some factors possibly linked to the development of allograft-correlated complications. Methods. Between December 1994 and March 2002, 23 patients with infected vascular prosthetic graft were treated at the Vascular Surgery Clinic, University of Pavia, IRCCS San Matteo Polyclinic. The patients were subjected to surgical removal of the infected prosthetic graft and in situ revascularisation through homologous arterial graft. Mean follow-up was 27.2 month (range 40 days-77.4 months). Results. In 2 cases it was impossible to implant the allograft: 1 for intraoperative decease of the patient, 1 for intraoperative rupture of the allograft. Overall mortality was 34.7%; the amputation rate was 13%. In 34.6% of cases no microorganism was isolated on culturing the explanted prosthetic graft. The rate of perioperative allograft-correlated complications was 30.5%, with mean onset at 6 days. The rate of late allograft-correlated complications was 39%, with mean onset at 25.9 months. No significant association was found between AB0 compatibility and development of allograft-correlated complications. A significant association was detected between lower risk of developing early complications and age of donor above 40 years. Conclusions. Among factors influencing the development of allograft-correlated complications, age of donor below 40 years and history of drug allergies were found to be associated with a higher risk of allograft-correlated complications.

KW - Aneurysm, infected

KW - Prosthesis related infections

KW - Transplantation, homologous

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M3 - Articolo

VL - 10

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EP - 346

JO - Giornale Italiano di Chirurgia Vascolare

JF - Giornale Italiano di Chirurgia Vascolare

SN - 1122-8679

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ER -