Arterial alterations in hypertension

Gino Seravalle, Guido Grassi, Giuseppe Mancia

Research output: Chapter in Book/Report/Conference proceedingChapter


Several metabolic, humoral, local, and neural influences contribute to the homeostatic control of the cardiovascular system. All these factors physiologically interact with each other and participate in the regulation of cardiac as well as vascular function. Both endothelial and sympathetic functions seem to be the main important regulatory mechanisms involved in maintaining the homeostatic balance and participating in the cardiovascular responses to environmental needs. The alterations of these mechanisms represent the key factor for the cardiovascular modifications typical of several clinical conditions, such as heart, kidney, lung, and liver diseases as well as obesity and diabetes and represent the target for non-pharmacologic and pharmacologic interventions.

Original languageEnglish
Title of host publicationArterial Disorders: Definition, Clinical Manifestations, Mechanisms and Therapeutic Approaches
PublisherSpringer International Publishing
Number of pages13
ISBN (Print)9783319145563, 9783319145556
Publication statusPublished - Jan 1 2015


  • Cardiovascular risk
  • Hypertension
  • Large arteries
  • Microcirculation
  • Target organ damage

ASJC Scopus subject areas

  • Medicine(all)


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