Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance: Incidence and risk factors in a cohort of 1491 patients

Tommaso Za, Valerio De Stefano, Elena Rossi, Maria Teresa Petrucci, Alessandro Andriani, Luciana Annino, Giuseppe Cimino, Tommaso Caravita, Francesco Pisani, Angela Ciminello, Fabio Torelli, Nicoletta Villivà, Velia Bongarzoni, Angela Rago, Silvia Betti, Anna Levi, Stefano Felici, Fabiana Gentilini, Elisabetta Calabrese, Giuseppe Leone

Research output: Contribution to journalArticle

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) has been associated with an increased risk of thrombosis. We carried out a retrospective multicentre cohort study on 1491 patients with MGUS. In 49 patients (3·3%) MGUS was diagnosed after a thrombotic event. Follow-up details for a period of at least 12months after diagnosis of MGUS were obtained in 1238 patients who had no recent history of thrombosis (16g/l at diagnosis (HR 3·08, 95%CI 1·01-9·36). No thrombosis was recorded in patients who developed multiple myeloma (n=50) or other neoplastic diseases (n=21). The incidence of arterial or venous thrombosis in patients with MGUS did not increase relative to that reported in the general population for similarly aged members. Finally, the risk of venous thrombosis did increase when the M-protein concentration exceeded >16g/l.

Original languageEnglish
Pages (from-to)673-679
Number of pages7
JournalBritish Journal of Haematology
Volume160
Issue number5
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Arterial thrombosis
  • Monoclonal gammopathy of undetermined significance
  • Venous thrombosis

ASJC Scopus subject areas

  • Hematology

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    Za, T., De Stefano, V., Rossi, E., Petrucci, M. T., Andriani, A., Annino, L., Cimino, G., Caravita, T., Pisani, F., Ciminello, A., Torelli, F., Villivà, N., Bongarzoni, V., Rago, A., Betti, S., Levi, A., Felici, S., Gentilini, F., Calabrese, E., & Leone, G. (2013). Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance: Incidence and risk factors in a cohort of 1491 patients. British Journal of Haematology, 160(5), 673-679. https://doi.org/10.1111/bjh.12168