Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance

Incidence and risk factors in a cohort of 1491 patients

Tommaso Za, Valerio De Stefano, Elena Rossi, Maria Teresa Petrucci, Alessandro Andriani, Luciana Annino, Giuseppe Cimino, Tommaso Caravita, Francesco Pisani, Angela Ciminello, Fabio Torelli, Nicoletta Villivà, Velia Bongarzoni, Angela Rago, Silvia Betti, Anna Levi, Stefano Felici, Fabiana Gentilini, Elisabetta Calabrese, Giuseppe Leone

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) has been associated with an increased risk of thrombosis. We carried out a retrospective multicentre cohort study on 1491 patients with MGUS. In 49 patients (3·3%) MGUS was diagnosed after a thrombotic event. Follow-up details for a period of at least 12months after diagnosis of MGUS were obtained in 1238 patients who had no recent history of thrombosis (16g/l at diagnosis (HR 3·08, 95%CI 1·01-9·36). No thrombosis was recorded in patients who developed multiple myeloma (n=50) or other neoplastic diseases (n=21). The incidence of arterial or venous thrombosis in patients with MGUS did not increase relative to that reported in the general population for similarly aged members. Finally, the risk of venous thrombosis did increase when the M-protein concentration exceeded >16g/l.

Original languageEnglish
Pages (from-to)673-679
Number of pages7
JournalBritish Journal of Haematology
Volume160
Issue number5
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Monoclonal Gammopathy of Undetermined Significance
Venous Thrombosis
Incidence
Thrombosis
Multiple Myeloma
Multicenter Studies
Cohort Studies
Population
Proteins

Keywords

  • Arterial thrombosis
  • Monoclonal gammopathy of undetermined significance
  • Venous thrombosis

ASJC Scopus subject areas

  • Hematology

Cite this

Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance : Incidence and risk factors in a cohort of 1491 patients. / Za, Tommaso; De Stefano, Valerio; Rossi, Elena; Petrucci, Maria Teresa; Andriani, Alessandro; Annino, Luciana; Cimino, Giuseppe; Caravita, Tommaso; Pisani, Francesco; Ciminello, Angela; Torelli, Fabio; Villivà, Nicoletta; Bongarzoni, Velia; Rago, Angela; Betti, Silvia; Levi, Anna; Felici, Stefano; Gentilini, Fabiana; Calabrese, Elisabetta; Leone, Giuseppe.

In: British Journal of Haematology, Vol. 160, No. 5, 03.2013, p. 673-679.

Research output: Contribution to journalArticle

Za, T, De Stefano, V, Rossi, E, Petrucci, MT, Andriani, A, Annino, L, Cimino, G, Caravita, T, Pisani, F, Ciminello, A, Torelli, F, Villivà, N, Bongarzoni, V, Rago, A, Betti, S, Levi, A, Felici, S, Gentilini, F, Calabrese, E & Leone, G 2013, 'Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance: Incidence and risk factors in a cohort of 1491 patients', British Journal of Haematology, vol. 160, no. 5, pp. 673-679. https://doi.org/10.1111/bjh.12168
Za, Tommaso ; De Stefano, Valerio ; Rossi, Elena ; Petrucci, Maria Teresa ; Andriani, Alessandro ; Annino, Luciana ; Cimino, Giuseppe ; Caravita, Tommaso ; Pisani, Francesco ; Ciminello, Angela ; Torelli, Fabio ; Villivà, Nicoletta ; Bongarzoni, Velia ; Rago, Angela ; Betti, Silvia ; Levi, Anna ; Felici, Stefano ; Gentilini, Fabiana ; Calabrese, Elisabetta ; Leone, Giuseppe. / Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance : Incidence and risk factors in a cohort of 1491 patients. In: British Journal of Haematology. 2013 ; Vol. 160, No. 5. pp. 673-679.
@article{1d43f99725d54421af28571b6f0dc285,
title = "Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance: Incidence and risk factors in a cohort of 1491 patients",
abstract = "Monoclonal gammopathy of undetermined significance (MGUS) has been associated with an increased risk of thrombosis. We carried out a retrospective multicentre cohort study on 1491 patients with MGUS. In 49 patients (3·3{\%}) MGUS was diagnosed after a thrombotic event. Follow-up details for a period of at least 12months after diagnosis of MGUS were obtained in 1238 patients who had no recent history of thrombosis (16g/l at diagnosis (HR 3·08, 95{\%}CI 1·01-9·36). No thrombosis was recorded in patients who developed multiple myeloma (n=50) or other neoplastic diseases (n=21). The incidence of arterial or venous thrombosis in patients with MGUS did not increase relative to that reported in the general population for similarly aged members. Finally, the risk of venous thrombosis did increase when the M-protein concentration exceeded >16g/l.",
keywords = "Arterial thrombosis, Monoclonal gammopathy of undetermined significance, Venous thrombosis",
author = "Tommaso Za and {De Stefano}, Valerio and Elena Rossi and Petrucci, {Maria Teresa} and Alessandro Andriani and Luciana Annino and Giuseppe Cimino and Tommaso Caravita and Francesco Pisani and Angela Ciminello and Fabio Torelli and Nicoletta Villiv{\`a} and Velia Bongarzoni and Angela Rago and Silvia Betti and Anna Levi and Stefano Felici and Fabiana Gentilini and Elisabetta Calabrese and Giuseppe Leone",
year = "2013",
month = "3",
doi = "10.1111/bjh.12168",
language = "English",
volume = "160",
pages = "673--679",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "5",

}

TY - JOUR

T1 - Arterial and venous thrombosis in patients with monoclonal gammopathy of undetermined significance

T2 - Incidence and risk factors in a cohort of 1491 patients

AU - Za, Tommaso

AU - De Stefano, Valerio

AU - Rossi, Elena

AU - Petrucci, Maria Teresa

AU - Andriani, Alessandro

AU - Annino, Luciana

AU - Cimino, Giuseppe

AU - Caravita, Tommaso

AU - Pisani, Francesco

AU - Ciminello, Angela

AU - Torelli, Fabio

AU - Villivà, Nicoletta

AU - Bongarzoni, Velia

AU - Rago, Angela

AU - Betti, Silvia

AU - Levi, Anna

AU - Felici, Stefano

AU - Gentilini, Fabiana

AU - Calabrese, Elisabetta

AU - Leone, Giuseppe

PY - 2013/3

Y1 - 2013/3

N2 - Monoclonal gammopathy of undetermined significance (MGUS) has been associated with an increased risk of thrombosis. We carried out a retrospective multicentre cohort study on 1491 patients with MGUS. In 49 patients (3·3%) MGUS was diagnosed after a thrombotic event. Follow-up details for a period of at least 12months after diagnosis of MGUS were obtained in 1238 patients who had no recent history of thrombosis (16g/l at diagnosis (HR 3·08, 95%CI 1·01-9·36). No thrombosis was recorded in patients who developed multiple myeloma (n=50) or other neoplastic diseases (n=21). The incidence of arterial or venous thrombosis in patients with MGUS did not increase relative to that reported in the general population for similarly aged members. Finally, the risk of venous thrombosis did increase when the M-protein concentration exceeded >16g/l.

AB - Monoclonal gammopathy of undetermined significance (MGUS) has been associated with an increased risk of thrombosis. We carried out a retrospective multicentre cohort study on 1491 patients with MGUS. In 49 patients (3·3%) MGUS was diagnosed after a thrombotic event. Follow-up details for a period of at least 12months after diagnosis of MGUS were obtained in 1238 patients who had no recent history of thrombosis (16g/l at diagnosis (HR 3·08, 95%CI 1·01-9·36). No thrombosis was recorded in patients who developed multiple myeloma (n=50) or other neoplastic diseases (n=21). The incidence of arterial or venous thrombosis in patients with MGUS did not increase relative to that reported in the general population for similarly aged members. Finally, the risk of venous thrombosis did increase when the M-protein concentration exceeded >16g/l.

KW - Arterial thrombosis

KW - Monoclonal gammopathy of undetermined significance

KW - Venous thrombosis

UR - http://www.scopus.com/inward/record.url?scp=84873998358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873998358&partnerID=8YFLogxK

U2 - 10.1111/bjh.12168

DO - 10.1111/bjh.12168

M3 - Article

VL - 160

SP - 673

EP - 679

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 5

ER -