TY - JOUR
T1 - Arterial distensibility in humans. Modulating mechanisms, alterations in diseases and effects of treatment
AU - Giannattasio, Cristina
AU - Mancia, Giuseppe
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Reduction of large artery distensibility has several adverse consequences for the cardiovascular system. This paper reviews the evidence obtained by measuring distensibility through quantification of changes in arterial diameter versus blood pressure changes at large elastic and middle size muscle artery sites. Evidence is available that arterial distensibility is reduced in conditions as varied as hypercholesterolemia, hypertension, diabetes and congestive heart failure. In some conditions (e.g. hypertension) the alterations are not uniformly distributed in arteries of different structure and size whereas in others (e.g. diabetes and heart failure) they are widespread. In diabetes evidence is available that distensibility changes occur early in the course of the disease. Evidence is also available that in all above conditions treatment can improve arterial distensibility thereby reversing the initial abnormality. This appears to be due to a variable combination of structural and functional factors. Technical ability to determine their precise role in distensibility changes in humans is limited, however.
AB - Reduction of large artery distensibility has several adverse consequences for the cardiovascular system. This paper reviews the evidence obtained by measuring distensibility through quantification of changes in arterial diameter versus blood pressure changes at large elastic and middle size muscle artery sites. Evidence is available that arterial distensibility is reduced in conditions as varied as hypercholesterolemia, hypertension, diabetes and congestive heart failure. In some conditions (e.g. hypertension) the alterations are not uniformly distributed in arteries of different structure and size whereas in others (e.g. diabetes and heart failure) they are widespread. In diabetes evidence is available that distensibility changes occur early in the course of the disease. Evidence is also available that in all above conditions treatment can improve arterial distensibility thereby reversing the initial abnormality. This appears to be due to a variable combination of structural and functional factors. Technical ability to determine their precise role in distensibility changes in humans is limited, however.
KW - Arterial distensibility
KW - Arterial vessels
KW - Atherosclerosis
KW - Treatment
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U2 - 10.1097/00004872-200210000-00001
DO - 10.1097/00004872-200210000-00001
M3 - Article
C2 - 12359960
AN - SCOPUS:0036807564
VL - 20
SP - 1889
EP - 1899
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 10
ER -