Ipertensione arteriosa e rischio cardiovascolare globale: Necessità di una strategia d'intervento combinata

Translated title of the contribution: Arterial hypertension and cardiovascular risk: Need for a combined strategy of intervention

V. Paoletti, V. Raparelli, P. Ferroni, A. Scarno, F. Trinchieri, Stefania Basili, G. Davì

Research output: Contribution to journalArticle

Abstract

Arterial hypertension represents one of the most common conditions associated with an increased cardiovascular risk. New evidences support the need to adopt a global approach to the treatment of cardiovascular risk in hypertensive subjects by using drugs with proven benefits, not only for blood pressure control, but also for their pleiotropic effects. A greater understanding of the pathogenetic mechanisms of hypertension would provide a better strategy for preventing and treating this condition. Angiotensin II seems to be responsible for triggering vascular inflammation by inducing oxidative stress, resulting in up-regulation of pro-inflammatory mediators that lead to endothelial dysfunction and vascular injury. The interaction of angiotensin II, oxidative stress and endothelial dysfunction might be a target of a new integrated approach with important clinical implications.

Translated title of the contributionArterial hypertension and cardiovascular risk: Need for a combined strategy of intervention
Original languageItalian
Pages (from-to)269-273
Number of pages5
JournalClinica Terapeutica
Volume159
Issue number4
Publication statusPublished - Jul 2008

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Paoletti, V., Raparelli, V., Ferroni, P., Scarno, A., Trinchieri, F., Basili, S., & Davì, G. (2008). Ipertensione arteriosa e rischio cardiovascolare globale: Necessità di una strategia d'intervento combinata. Clinica Terapeutica, 159(4), 269-273.