Abstract
Arterial hypertension represents one of the most common conditions associated with an increased cardiovascular risk. New evidences support the need to adopt a global approach to the treatment of cardiovascular risk in hypertensive subjects by using drugs with proven benefits, not only for blood pressure control, but also for their pleiotropic effects. A greater understanding of the pathogenetic mechanisms of hypertension would provide a better strategy for preventing and treating this condition. Angiotensin II seems to be responsible for triggering vascular inflammation by inducing oxidative stress, resulting in up-regulation of pro-inflammatory mediators that lead to endothelial dysfunction and vascular injury. The interaction of angiotensin II, oxidative stress and endothelial dysfunction might be a target of a new integrated approach with important clinical implications.
Translated title of the contribution | Arterial hypertension and cardiovascular risk: Need for a combined strategy of intervention |
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Original language | Italian |
Pages (from-to) | 269-273 |
Number of pages | 5 |
Journal | Clinica Terapeutica |
Volume | 159 |
Issue number | 4 |
Publication status | Published - Jul 2008 |
ASJC Scopus subject areas
- Medicine(all)