Arterial hypertension in cancer: The elephant in the room

Giacomo Tini, Matteo Sarocchi, Giuliano Tocci, Eleonora Arboscello, Giorgio Ghigliotti, Giuseppina Novo, Claudio Brunelli, Daniel Lenihan, Massimo Volpe, Paolo Spallarossa

Research output: Contribution to journalArticlepeer-review

Abstract

The great therapeutical success achieved by oncology is counterbalanced by growing evidences of cardiovascular (CV) toxicity due to many antineoplastic treatments. Cardiac adverse events may cause premature discontinuation of effective oncologic treatments or occur as late events undermining the oncologic success. Arterial hypertension is both the most common comorbidity in cancer patients and a frequent adverse effect of anticancer therapies. A pre-existing hypertension is known to increase the risk of other cardiac adverse events due to oncologic treatments, in particular heart failure. Moreover, as a strict association between cancer and CV diseases has emerged over the recent years, various analyses have shown a direct relationship between hypertension and cancer incidence and mortality. Finally, many antineoplastic treatments may cause a rise in blood pressure (BP) values, particularly the novel anti VEGF agents, this possibly compromising efficacy of chemotherapy. Aim of this review is to revise the topic and the many aspects linking arterial hypertension and cancer, and to provide a comprehensive and practical guide of the current treatment approaches.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalInternational Journal of Cardiology
Volume281
DOIs
Publication statusPublished - Apr 15 2019

Keywords

  • Anthracyclines
  • Anti VEGF agents
  • Anti-hypertensive therapy
  • Arterial hypertension
  • Cancer
  • Cardiotoxicity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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