Arterial hypertension increases left ventricular mass: Role of tight blood pressure control

L. A. Ferrara, O. Vaccaro, O. Cardoni, M. Mancini, A. Zanchetti

Research output: Contribution to journalArticlepeer-review


In middle-age hypertensives from the Gubbio Population Study, we evaluated the relationship between blood pressure (BP) control over a long time and the prevalence of left ventricular hypertrophy (LVH). A population survey was performed in 1982-1985 and repeated in 1989-1992. During the second survey, subjects in the age range 40-60 years were invited to undergo an M-mode echocardiographic examination. A total of 487 subjects who participated in both surveys are included in the present analysis. Some of them (294) were normotensive (Group 1), 110 were hypertensive but had never taken antihypertensive drugs (Group 2), 47 hypertensives on drugs were in good BP control (Group 3) and 36 hypertensives on drugs had uncontrolled hypertension (Group 4). BP values at the 1989-1992 examination were, respectively, 122/77, 145/86, 124/78 and 153/91 mmHg, while 7 years earlier were 122/77, 133/84, 136/85 and 152/95 mmHg. Despite normal BP levels in Group 3, left ventricular mass index (LVMi, g/m2.7) was greater than in normotensives (42.4±10, 46.6±13, 47.0±10, 51.9±15g/m2.7). Accordingly, the prevalence of LVH (LVMi >51 g/m2.7) was 18, 26.4, 36.7 and 50% in groups 1-4, respectively. The 193 hypertensives were, thereafter, divided according to BP control (ie

Original languageEnglish
Pages (from-to)637-642
Number of pages6
JournalJournal of Human Hypertension
Issue number9
Publication statusPublished - Sep 2004


  • Blood pressure control
  • End-organ damage
  • Gubbio population study
  • Left ventricular hypertrophy

ASJC Scopus subject areas

  • Internal Medicine


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