Arterial properties in relation to genetic variations in the adducin subunits in a white population

Jitka Seidlerová, Jan A. Staessen, Murielle Bochud, Tim Nawrot, Nunzia Casamassima, Lorena Citterio, Tatiana Kuznetsova, Yu Jin, Paulo Manunta, Tom Richart, Harry A. Struijker-Boudier, Robert Fagard, Jan Filipovský, Giuseppe Bianchi

Research output: Contribution to journalArticle

Abstract

Background: Adducin is a membrane skeleton protein, which consists of either α- and β- or α- and γ-subunits. We investigated whether arterial characteristics might be related to the genes encoding ADD1 (Gly460Trp-rs4961), ADD2 (C1797T-rs4984), and ADD3 (IVS11+386A>G-rs3731566). Methods: We randomly recruited 1,126 Flemish subjects (mean age, 43.8 years; 50.3% women). Using a wall-tracking ultrasound system, we measured the properties of the carotid, femoral, and brachial arteries. We studied multivariate-adjusted phenotype-genotype associations, using a population- and family-based approach. Results: In single-gene analyses, brachial diameter was 0.15 mm (P = 0.0022) larger, and brachial distensibility and cross-sectional compliance were 1.55 × 10-3/kPa (P = 0.013) and 0.017 mm 2/kPa (P = 0.0029) lower in ADD3 AA than ADD3 GG homozygotes with an additive effect of the G allele. In multiple-gene analyses, the association of brachial diameter and distensibility with the ADD3 G allele occurred only in ADD1 GlyGly homozygotes. Otherwise, the associations between the arterial phenotypes in the three vascular beds and the ADD1 or ADD2 polymorphisms were not significant. In family-based analyses, the multivariate-adjusted heritability was 0.52, 0.38, and 0.30 for brachial diameter, distensibility, and cross-sectional compliance, respectively (P <0.001). There was no evidence for population stratification (0.07 ≤ P ≤ 0.96). Transmission of the mutated ADD3 G allele was associated with smaller brachial diameter in 342 informative offspring (-0.12 ± 0.04 mm; P = 0.0085) and in 209 offspring, who were ADD1 GlyGly homozygotes (-0.14 ± 0.06 mm; P = 0.018). Conclusions: In ADD1 GlyGly homozygotes, the properties of the brachial artery are related to the ADD3 (A386G) polymorphism, but the underlying mechanism needs further clarification.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalAmerican Journal of Hypertension
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 2009

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Homozygote
Arm
Brachial Artery
Population
Alleles
Compliance
Genes
Genetic Association Studies
Femoral Artery
Carotid Arteries
Skeleton
Blood Vessels
Membrane Proteins
Multivariate Analysis
adducin
Phenotype

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Seidlerová, J., Staessen, J. A., Bochud, M., Nawrot, T., Casamassima, N., Citterio, L., ... Bianchi, G. (2009). Arterial properties in relation to genetic variations in the adducin subunits in a white population. American Journal of Hypertension, 22(1), 21-26. https://doi.org/10.1038/ajh.2008.261

Arterial properties in relation to genetic variations in the adducin subunits in a white population. / Seidlerová, Jitka; Staessen, Jan A.; Bochud, Murielle; Nawrot, Tim; Casamassima, Nunzia; Citterio, Lorena; Kuznetsova, Tatiana; Jin, Yu; Manunta, Paulo; Richart, Tom; Struijker-Boudier, Harry A.; Fagard, Robert; Filipovský, Jan; Bianchi, Giuseppe.

In: American Journal of Hypertension, Vol. 22, No. 1, 01.2009, p. 21-26.

Research output: Contribution to journalArticle

Seidlerová, J, Staessen, JA, Bochud, M, Nawrot, T, Casamassima, N, Citterio, L, Kuznetsova, T, Jin, Y, Manunta, P, Richart, T, Struijker-Boudier, HA, Fagard, R, Filipovský, J & Bianchi, G 2009, 'Arterial properties in relation to genetic variations in the adducin subunits in a white population', American Journal of Hypertension, vol. 22, no. 1, pp. 21-26. https://doi.org/10.1038/ajh.2008.261
Seidlerová, Jitka ; Staessen, Jan A. ; Bochud, Murielle ; Nawrot, Tim ; Casamassima, Nunzia ; Citterio, Lorena ; Kuznetsova, Tatiana ; Jin, Yu ; Manunta, Paulo ; Richart, Tom ; Struijker-Boudier, Harry A. ; Fagard, Robert ; Filipovský, Jan ; Bianchi, Giuseppe. / Arterial properties in relation to genetic variations in the adducin subunits in a white population. In: American Journal of Hypertension. 2009 ; Vol. 22, No. 1. pp. 21-26.
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author = "Jitka Seidlerov{\'a} and Staessen, {Jan A.} and Murielle Bochud and Tim Nawrot and Nunzia Casamassima and Lorena Citterio and Tatiana Kuznetsova and Yu Jin and Paulo Manunta and Tom Richart and Struijker-Boudier, {Harry A.} and Robert Fagard and Jan Filipovsk{\'y} and Giuseppe Bianchi",
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AU - Staessen, Jan A.

AU - Bochud, Murielle

AU - Nawrot, Tim

AU - Casamassima, Nunzia

AU - Citterio, Lorena

AU - Kuznetsova, Tatiana

AU - Jin, Yu

AU - Manunta, Paulo

AU - Richart, Tom

AU - Struijker-Boudier, Harry A.

AU - Fagard, Robert

AU - Filipovský, Jan

AU - Bianchi, Giuseppe

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N2 - Background: Adducin is a membrane skeleton protein, which consists of either α- and β- or α- and γ-subunits. We investigated whether arterial characteristics might be related to the genes encoding ADD1 (Gly460Trp-rs4961), ADD2 (C1797T-rs4984), and ADD3 (IVS11+386A>G-rs3731566). Methods: We randomly recruited 1,126 Flemish subjects (mean age, 43.8 years; 50.3% women). Using a wall-tracking ultrasound system, we measured the properties of the carotid, femoral, and brachial arteries. We studied multivariate-adjusted phenotype-genotype associations, using a population- and family-based approach. Results: In single-gene analyses, brachial diameter was 0.15 mm (P = 0.0022) larger, and brachial distensibility and cross-sectional compliance were 1.55 × 10-3/kPa (P = 0.013) and 0.017 mm 2/kPa (P = 0.0029) lower in ADD3 AA than ADD3 GG homozygotes with an additive effect of the G allele. In multiple-gene analyses, the association of brachial diameter and distensibility with the ADD3 G allele occurred only in ADD1 GlyGly homozygotes. Otherwise, the associations between the arterial phenotypes in the three vascular beds and the ADD1 or ADD2 polymorphisms were not significant. In family-based analyses, the multivariate-adjusted heritability was 0.52, 0.38, and 0.30 for brachial diameter, distensibility, and cross-sectional compliance, respectively (P <0.001). There was no evidence for population stratification (0.07 ≤ P ≤ 0.96). Transmission of the mutated ADD3 G allele was associated with smaller brachial diameter in 342 informative offspring (-0.12 ± 0.04 mm; P = 0.0085) and in 209 offspring, who were ADD1 GlyGly homozygotes (-0.14 ± 0.06 mm; P = 0.018). Conclusions: In ADD1 GlyGly homozygotes, the properties of the brachial artery are related to the ADD3 (A386G) polymorphism, but the underlying mechanism needs further clarification.

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