TY - JOUR
T1 - Arterial stiffening influence of sympathetic nerve activity
T2 - Evidence from hand transplantation in humans
AU - Giannattasio, Cristina
AU - Failla, Monica
AU - Lucchina, Stefano
AU - Zazzeron, Chiara
AU - Scotti, Valentina
AU - Capra, Anna
AU - Viscardi, Luigina
AU - Bianchi, Francesca
AU - Vitale, Giovanni
AU - Lanzetta, Marco
AU - Mancia, Giuseppe
PY - 2005/4
Y1 - 2005/4
N2 - Studies in animals and humans suggest that sympathetic activity exerts a stiffening influence on large and middle-sized artery walls. We sought to obtain further evidence on this issue by measuring radial artery distensibility in an allotransplanted and thus denervated hand using the contralateral artery as control. In 2 men, blood pressure was measured by a semiautomatic device (Dinamap). Diastolic diameter, systo-diastolic diameter excursion (ultrasound Wall Track system), and distensibility (Reneman formula) of both radial arteries were measured at a level corresponding to 4 cm below the suture of the transplanted hand 40 days after surgery and every 4 weeks for the next 6 months. After surgery, systo-diastolic diameter excursion and distensibility were much greater in the transplanted radial artery than in the contralateral vessel, reaching values similar to the contralateral ones after 4 months, when signs of reinnervation of the transplanted hands had appeared. Radial deinnervation was accompanied by an increased arterial distensibility, which provides further evidence of the sympathetic stiffening effect on arterial wall in humans.
AB - Studies in animals and humans suggest that sympathetic activity exerts a stiffening influence on large and middle-sized artery walls. We sought to obtain further evidence on this issue by measuring radial artery distensibility in an allotransplanted and thus denervated hand using the contralateral artery as control. In 2 men, blood pressure was measured by a semiautomatic device (Dinamap). Diastolic diameter, systo-diastolic diameter excursion (ultrasound Wall Track system), and distensibility (Reneman formula) of both radial arteries were measured at a level corresponding to 4 cm below the suture of the transplanted hand 40 days after surgery and every 4 weeks for the next 6 months. After surgery, systo-diastolic diameter excursion and distensibility were much greater in the transplanted radial artery than in the contralateral vessel, reaching values similar to the contralateral ones after 4 months, when signs of reinnervation of the transplanted hands had appeared. Radial deinnervation was accompanied by an increased arterial distensibility, which provides further evidence of the sympathetic stiffening effect on arterial wall in humans.
KW - Denervation
KW - Sympathetic nervous system
KW - Transplantation
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U2 - 10.1161/01.HYP.0000157368.09939.88
DO - 10.1161/01.HYP.0000157368.09939.88
M3 - Article
C2 - 15699439
AN - SCOPUS:20144372357
VL - 45
SP - 608
EP - 611
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 4
ER -