Arterial stiffness and left ventricular performance in elderly patients with persistent atrial fibrillation

Stefano Fumagalli, Marta Migliorini, Simone Pupo, Irene Marozzi, Serena Boni, Alessandra Scardia, Alessandro Masi, Anna T Roberts, Luigi Padeletti, Niccolò Marchionni

Research output: Contribution to journalArticlepeer-review


BACKGROUND: The prevalence of atrial fibrillation (AF) and arterial stiffness (AS) increases with age.

AIMS: To evaluate if AS is correlated to longitudinal strain (LS), a marker of left ventricular (LV) function, in elderly AF patients with preserved ejection fraction (EF) undergoing external cardioversion.

METHODS: AS was measured using the cardio-ankle vascular index (CAVI), LS was calculated from echocardiographic data of three consecutive cardiac cycles.

RESULTS: We enrolled 38 patients (age 76 ± 8 years; men 60.5%; EF 65 ± 7%). LS and CAVI were, respectively, - 17.7 ± 3.7% and 9.7 ± 1.3. Multivariate analysis showed that LV performance was inversely related to height (p < 0.001) and to the presence of AF-related symptoms (p = 0.008). LS grew with increasing values of CAVI (p = 0.038).

CONCLUSIONS: In elderly AF patients with preserved systolic function, LV performance is directly associated with AS. This link could influence atrium remodeling and the incidence of arrhythmia relapse.

Original languageEnglish
Pages (from-to)1403-1408
Number of pages6
JournalAging clinical and experimental research
Issue number11
Publication statusPublished - Nov 2018


  • Aged
  • Aged, 80 and over
  • Atrial Fibrillation/complications
  • Echocardiography
  • Electric Countershock
  • Female
  • Humans
  • Male
  • Multivariate Analysis
  • Vascular Stiffness
  • Ventricular Function, Left


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