Arterial-venous shunting in liver cirrhosis

Gianpaolo Molino, Fabrizio Bar, Stefania Battista, Mauro Torchio, Anna Grazia Niro, Enrico Garello, Paolo Avagnina, Cesare Fava, Maurizio Grosso, Francesco Spalluto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Controversial data exist in the literature about the presence and clinical relevance of hepatic arterial-venous shunting. An interesting opportunity for reconsidering the problem has been provided by the use, in the study of liver function, of D-sorbitol, a substance whose first-pass hepatic extraction is very high in normal subjects, while being directly related to circulatory alterations in liver cirrhosis. Because of this property, the systemic bioavailability of D-sorbitol during hepatic arterial infusion can be assumed to reflect arterial-venous shunting. Thirteen biopsy-proven cirrhotic patients (ages 35-66 years), who required diagnostic arterial catheterization, entered the study. Patients were studied on two subsequent days, in which a sterile pyrogen-free solution (1.5%) of D-sorbitol was administered by direct low-rate infusion (15 mg/min for 20 min) into the hepatic artery and the systemic circulation, respectively. Urine samples were spontaneously collected for 8-hr periods before and during/after each infusion. The hepatic arterial bioavailability of D-sorbitol was calculated as the ratio between the net cumulative urinary outputs of D-sorbitol after infusions into the hepatic artery and the systemic vein. Observed values confirm the existence and the large variability (0-88.7%) of hepatic arterial-venous shunting in cirrhotic patients.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalDigestive Diseases and Sciences
Volume43
Issue number1
DOIs
Publication statusPublished - 1998

Fingerprint

Sorbitol
Liver Cirrhosis
Liver
Hepatic Artery
Biological Availability
Pyrogens
Catheterization
Veins
Urine
Biopsy

Keywords

  • D-sorbitol
  • Hepatic arterial-venous shunting
  • Hepatic bioavailability
  • Liver circulation
  • Liver cirrhosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Molino, G., Bar, F., Battista, S., Torchio, M., Niro, A. G., Garello, E., ... Spalluto, F. (1998). Arterial-venous shunting in liver cirrhosis. Digestive Diseases and Sciences, 43(1), 51-55. https://doi.org/10.1023/A:1018867819339

Arterial-venous shunting in liver cirrhosis. / Molino, Gianpaolo; Bar, Fabrizio; Battista, Stefania; Torchio, Mauro; Niro, Anna Grazia; Garello, Enrico; Avagnina, Paolo; Fava, Cesare; Grosso, Maurizio; Spalluto, Francesco.

In: Digestive Diseases and Sciences, Vol. 43, No. 1, 1998, p. 51-55.

Research output: Contribution to journalArticle

Molino, G, Bar, F, Battista, S, Torchio, M, Niro, AG, Garello, E, Avagnina, P, Fava, C, Grosso, M & Spalluto, F 1998, 'Arterial-venous shunting in liver cirrhosis', Digestive Diseases and Sciences, vol. 43, no. 1, pp. 51-55. https://doi.org/10.1023/A:1018867819339
Molino, Gianpaolo ; Bar, Fabrizio ; Battista, Stefania ; Torchio, Mauro ; Niro, Anna Grazia ; Garello, Enrico ; Avagnina, Paolo ; Fava, Cesare ; Grosso, Maurizio ; Spalluto, Francesco. / Arterial-venous shunting in liver cirrhosis. In: Digestive Diseases and Sciences. 1998 ; Vol. 43, No. 1. pp. 51-55.
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