Arterio-jugular difference of oxygen content and outcome after head injury

Nino Stocchetti, Katia Canavesi, Sandra Magnoni, Valerio Valeriani, Valeria Conte, Sandra Rossi, Luca Longhi, Elisa Roncati Zanier, Angelo Colombo

Research output: Contribution to journalArticlepeer-review


This study investigated AJDo2 (arterio-jugular difference of oxygen content) in a large sample of severely head-injured patients to identify its pattern during the first days after injury and to describe the relationship of AJDo2 with acute neurological severity and with outcome 6 mo after trauma. In 229 comatose head-injured patients, we monitored intracranial pressure, cerebral perfusion pressure, and AJDo2. Outcome was defined 6 mo after injury. Jugular hemoglobin oxygen saturation (Sjo2) averaged 68%. The mean AJDo2 was 4.24 vol% (SD, 1.3 vol%). There were 80 measurements (4.6%) with Sjo2 75%. AJDo2 was higher than 8.7 vol% in 8 measurements (0.4%) and was lower than 3.9 vol% in 718 (42%) measurements. AJDo2 was higher during the first tests and decreased steadily over the next few days. Cases with a favorable outcome had a higher mean AJDo2 (4.3 vol%; SD, 0.3 vol%) than patients with severe disability or vegetative status (3.8 vol%; SD, 1.3 vol%) and patients who died (3.6 vol%; SD, 1 vol%). This difference was significant (P <0.001). We conclude that low levels of AJDo2 are correlated with a poor prognosis, whereas normal or high levels of AJDo2 are predictive of better results.

Original languageEnglish
Pages (from-to)230-234
Number of pages5
JournalAnesthesia and Analgesia
Issue number1
Publication statusPublished - Jul 2004

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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