Artificial lung

Research output: Contribution to journalReview article

Abstract

Lung transplantation remains the definitive curative treatment for end-stage lung disease. However, future applications of tissue bioengineering could overcome the donor organ shortage and the need for immunosuppression. The final goal of lung tissue engineering is to recreate the whole spectrum of specialized lung tissues and thereby provide physiologic functions through bioengineered conducting airways, vasculature and gas exchange tissue. This review focuses on ongoing research in artificial lung development, open questions, achievements to date and how tissue engineering and stem cell technology may further contribute to the clinical application of bioartificial lungs. Although experimental transplantation of bioartificial lung developed by perfusing decellularized or synthetic scaffolds has been shown to provide gas exchange in vivo over a prolonged period, it should be clearly acknowledged that the development of a transplantable bioartificial lung is far from reality.

Original languageEnglish
Pages (from-to)S2329-S2332
JournalJournal of Thoracic Disease
Volume10
Issue numberSuppl 20
DOIs
Publication statusPublished - Jul 2018

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Lung
Lung Transplantation
Tissue Engineering
Gases
Bioengineering
Immunosuppression
Lung Diseases
Stem Cells
Tissue Donors
Technology
Research
Therapeutics

Cite this

Artificial lung. / Petrella, Francesco; Spaggiari, Lorenzo.

In: Journal of Thoracic Disease, Vol. 10, No. Suppl 20, 07.2018, p. S2329-S2332.

Research output: Contribution to journalReview article

Petrella, Francesco ; Spaggiari, Lorenzo. / Artificial lung. In: Journal of Thoracic Disease. 2018 ; Vol. 10, No. Suppl 20. pp. S2329-S2332.
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