TY - JOUR
T1 - Artificial nutrition after major abdominal surgery
T2 - Impact of route of administration and composition of the diet
AU - Braga, Marco
AU - Gianotti, Luca
AU - Vignali, Andrea
AU - Cestari, Andrea
AU - Bisagni, Pietro
AU - Di Carlo, Valerio
PY - 1998
Y1 - 1998
N2 - Objective: To evaluate the impact of the route of administration of artificial nutrition and the composition of the diet on outcome. Design: Prospective, randomized, clinical trial. Setting: Department of surgery, university hospital. Patients: One hundred sixty-six consecutive patients undergoing curative surgery for gastric or pancreatic cancer. Interventions: At operation, the patients were randomized into three groups to receive: a) a standard enteral formula (control group; n = 55); b) the same enteral formula enriched with arginine, RNA, and omega-3 fatty acids (enriched group; n = 55); and c) total parenteral nutrition (TPN group; n = 56). The three regimens were isocaloric and isonitrogenous. Enteral nutrition was started within 12 hrs following surgery. The infusion rate was progressively increased to reach the nutritional goal (25 kcal/kg/day) on postoperative day 4. Measurements and Main Results: Tolerance of enteral feeding, rate and severity of postoperative complications, and length of hospital stay were recorded. Early enteral infusion was well tolerated. Side effects were recorded in 22.7% of the patients, but only 6.3% did not reach the nutritional goal. The enriched group had a lower severity of infection than the parenteral group (4.0 vs. 8.6; p
AB - Objective: To evaluate the impact of the route of administration of artificial nutrition and the composition of the diet on outcome. Design: Prospective, randomized, clinical trial. Setting: Department of surgery, university hospital. Patients: One hundred sixty-six consecutive patients undergoing curative surgery for gastric or pancreatic cancer. Interventions: At operation, the patients were randomized into three groups to receive: a) a standard enteral formula (control group; n = 55); b) the same enteral formula enriched with arginine, RNA, and omega-3 fatty acids (enriched group; n = 55); and c) total parenteral nutrition (TPN group; n = 56). The three regimens were isocaloric and isonitrogenous. Enteral nutrition was started within 12 hrs following surgery. The infusion rate was progressively increased to reach the nutritional goal (25 kcal/kg/day) on postoperative day 4. Measurements and Main Results: Tolerance of enteral feeding, rate and severity of postoperative complications, and length of hospital stay were recorded. Early enteral infusion was well tolerated. Side effects were recorded in 22.7% of the patients, but only 6.3% did not reach the nutritional goal. The enriched group had a lower severity of infection than the parenteral group (4.0 vs. 8.6; p
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U2 - 10.1097/00003246-199801000-00012
DO - 10.1097/00003246-199801000-00012
M3 - Article
C2 - 9428539
AN - SCOPUS:0031975493
VL - 26
SP - 24
EP - 30
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 1
ER -