Artificial nutrition and hydration in the last week of life in cancer patients. A systematic literature review of practices and effects

N. J H Raijmakers, L. van Zuylen, M. Costantini, A. Caraceni, J. Clark, G. Lundquist, R. Voltz, J. E. Ellershaw, A. van der Heide

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background: The benefits and burdens of artificial nutrition (AN) and artificial hydration (AH) in end-of-life care are unclear. We carried out a literature review on the use of AN and AH in the last days of life of cancer patients. Materials and methods: We systematically searched for papers in PubMed, CINAHL, PsycInfo and EMBASE. All English papers published between January 1998 and July 2009 that contained data on frequencies or effects of AN or AH in cancer patients in the last days of life were included. Results: Reported percentages of patients receiving AN or AH in the last week of life varied from 3% to 53% and from 12% to 88%, respectively. Five studies reported on the effects of AH: two found positive effects (less chronic nausea, less physical dehydration signs), two found negative effects (more ascites, more intestinal drainage) and four found also no effects on terminal delirium, thirst, chronic nausea and fluid overload. No study reported on the sole effect of AN. Conclusions: Providing AN or AH to cancer patients who are in the last week of life is a frequent practice. The effects on comfort, symptoms and length of survival seem limited. Further research will contribute to better understanding of this important topic in end-of-life care.

Original languageEnglish
Pages (from-to)1478-1486
Number of pages9
JournalAnnals of Oncology
Volume22
Issue number7
DOIs
Publication statusPublished - 2011

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Terminal Care
Nausea
Neoplasms
Thirst
Delirium
Dehydration
Ascites
PubMed
Drainage
Survival
Research

Keywords

  • Artificial hydration
  • Artificial nutrition
  • Dying phase
  • End of life
  • Palliative care
  • Terminal care

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Artificial nutrition and hydration in the last week of life in cancer patients. A systematic literature review of practices and effects. / Raijmakers, N. J H; van Zuylen, L.; Costantini, M.; Caraceni, A.; Clark, J.; Lundquist, G.; Voltz, R.; Ellershaw, J. E.; van der Heide, A.

In: Annals of Oncology, Vol. 22, No. 7, 2011, p. 1478-1486.

Research output: Contribution to journalArticle

Raijmakers, N. J H ; van Zuylen, L. ; Costantini, M. ; Caraceni, A. ; Clark, J. ; Lundquist, G. ; Voltz, R. ; Ellershaw, J. E. ; van der Heide, A. / Artificial nutrition and hydration in the last week of life in cancer patients. A systematic literature review of practices and effects. In: Annals of Oncology. 2011 ; Vol. 22, No. 7. pp. 1478-1486.
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