Ascites regression and survival increase in mice bearing advanced-stage human ovarian carcinomas and repeatedly treated intraperitoneally with CpG-ODN

Michelandrea De Cesare, Lucia Sfondrini, Manuela Campiglio, Michele Sommariva, Francesca Bianchi, Paola Perego, Nico Van Rooijen, Rosanna Supino, Cristiano Rumio, Franco Zunino, Graziella Pratesi, Elda Tagliabue, Andrea Balsari

Research output: Contribution to journalArticle

Abstract

Tumor cell growth, even in advanced stages of ovarian cancer, is nearly always restricted to the peritoneal cavity; therefore, repeated intraperitoneal injections of oligodeoxynucleotides containing dinucleotides with unmethylated CpG motifs (CpG-ODN) recruiting and activating innate effector cells throughout the abdominal cavity to the tumor site might control tumor cell growth and ascites formation. After a single CpG-ODN treatment, in IGROV-1 ovarian tumor ascites-bearing athymic mice, the number of tumor cells declined rapidly and markedly, and ascites volumes declined shortly after treatment (5h), increasing thereafter at a slower rate than in controls. When administered every 7 days for 4 weeks, CpG-ODN had only a marginal effect on survival time, whereas administration 5 days/wk for 3 or 4 weeks led to a significantly increased survival time as compared with controls (P

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalJournal of Immunotherapy
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Antitumor activity
  • Ascites
  • CpG-ODN
  • Orthotopic model
  • Ovarian cancer

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Cancer Research
  • Pharmacology

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  • Cite this

    De Cesare, M., Sfondrini, L., Campiglio, M., Sommariva, M., Bianchi, F., Perego, P., Van Rooijen, N., Supino, R., Rumio, C., Zunino, F., Pratesi, G., Tagliabue, E., & Balsari, A. (2010). Ascites regression and survival increase in mice bearing advanced-stage human ovarian carcinomas and repeatedly treated intraperitoneally with CpG-ODN. Journal of Immunotherapy, 33(1), 8-15. https://doi.org/10.1097/CJI.0b013e3181affaa7