Aspartame and the rat brain monoaminergic system

C. Perego, M. G. De Simoni, F. Fodritto, L. Raimondi, L. Diomede, M. Salmona, S. Algeri, S. Garattini

Research output: Contribution to journalArticle

Abstract

A high dose of aspartame (APM) was administered to rats to study possible effects on brain monoaminergic systems. APM and its metabolite phenylalanine (Phe) were given orally at doses of 1000 and 500 mg/kg, respectively. Significant increases were seen in brain Phe and tyrosine (Tyr) levels. Two different approaches were used to study monoaminergic systems: whole tissue measurements by HPLC-ED and in vivo voltammetry in freely moving rats. Dopamine, serotonin and their metabolites were taken as indexes of neuronal activity. In spite of the high dose used, no modification was found in monoamines or their metabolites in striatum, hippocampus and nucleus accumbens.

Original languageEnglish
Pages (from-to)331-339
Number of pages9
JournalToxicology Letters
Volume44
Issue number3
DOIs
Publication statusPublished - 1988

Fingerprint

Aspartame
Metabolites
Phenylalanine
Rats
Brain
Nucleus Accumbens
Tyrosine
Hippocampus
Dopamine
Serotonin
High Pressure Liquid Chromatography
Voltammetry
Tissue

Keywords

  • Aspartame
  • Dopaminergic system
  • Phenylalanine
  • Plasma and brain amino acids
  • Serotonergic system

ASJC Scopus subject areas

  • Toxicology

Cite this

Aspartame and the rat brain monoaminergic system. / Perego, C.; De Simoni, M. G.; Fodritto, F.; Raimondi, L.; Diomede, L.; Salmona, M.; Algeri, S.; Garattini, S.

In: Toxicology Letters, Vol. 44, No. 3, 1988, p. 331-339.

Research output: Contribution to journalArticle

Perego, C. ; De Simoni, M. G. ; Fodritto, F. ; Raimondi, L. ; Diomede, L. ; Salmona, M. ; Algeri, S. ; Garattini, S. / Aspartame and the rat brain monoaminergic system. In: Toxicology Letters. 1988 ; Vol. 44, No. 3. pp. 331-339.
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