ASPETTI DI DIAGNOSTICA ANGIOGRAFICA DIFFERENZIALE NELLE MASSE ESPANSIVE PANCREATICHE

Translated title of the contribution: Aspects of angiography in the differential diagnosis of swellings in the pancreas

R. Roversi, S. Moretti, G. Gavelli, L. De Florio

Research output: Contribution to journalArticlepeer-review

Abstract

An investigation was made into the occurrence of muscular atrophy and muscular pathology in a series of 170 patients with myasthenia gravis. The results can be summarized as follows: of the 148 patients with generalized myasthenia gravis, 14 showed local muscular atrophies. Of the 10 biopsies from atrophic muscles, eight showed neurogenic changes, with or without lymphocytic infiltrations. One biopsy showed lymphocytic infiltrations only and one showed type II fibers. No relationship was demonstrable between the presence of clinical muscular atrophy and age, sex, duration of the disease, severity of the disease, presence of a thymoma, or drug resistant ophthalmoplegia. In this group of patients 61 biopsies were examined from 46 individuals; 40 of these biopsies were taken from the quadriceps muscle. A thymoma was present in 17 patients. Examination disclosed neurogenic changes in 17 biopsies, lymphocytic infiltrates in 21, and myositis in one biopsy. A distinct correlation was established between the presence of a thymoma and lymphocytic infiltrates, but none was demonstrable between thymoma and neurogenic changes. A normal differentiation of type I and type II fibers was observed in eight instances, type grouping of type II fibers in three, and type II fiber atrophy in two cases. In 21 patients and 19 controls, the smallest mean diameter was determined in the quadriceps muscle. Both type I and type II fibers proved to have a smaller mean diameter in the female patients than in the controls. In the male patients this could not be proven. Of the eight patients who had died without disorders of ventilation, 90 muscle specimens were examined post mortem. Four of these patients had a thymoma. Lymphocytic infiltrations, found in 32 biopsy specimens, were mostly observed in the presence of a thymoma. Neurogenic changes were apparently unrelated to the presence of a thymoma. The post mortem examination included the spinal cord in five, and peripheral nerves in three cases. No abnormalities were found. The muscular atrophy found in patients with myasthenia is not a myopathy but an affection of the lower motor neurone. Neurogenic changes were regularly found in the muscles of patients with myasthenia, even without muscular atrophy. The finding of these changes is no reason to reject the diagnosis. It is postulated that denervation occurs at the neuromuscular junction as a result of permanent absence of acetylcholine.

Translated title of the contributionAspects of angiography in the differential diagnosis of swellings in the pancreas
Original languageItalian
Pages (from-to)15-34
Number of pages20
JournalRadiologia Medica
Volume59
Issue number1
Publication statusPublished - 1973

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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