Aspergillus fumigatus lung infection in HIV-positive subjects. Report of 3 cases

M. Bissolati, L. Cocchi, R. Giacchino, G. Poma, G. Michelone, P. Villani, R. Maserati

Research output: Contribution to journalArticle

Abstract

Pulmonary aspergillosis may present in HIV-infected patients in different ways, ranging from colonization to invasive disease. We have recently observed 3 cases of this opportunistic infection in previously asymptomatic HIV-positive patients (all males, former or active IVDAs, aged 28 to 34 years, with a mean CD4+ lymph, level of 66/mcL) who had never been hospitalized for HIV-related causes before. None of them had leukopenia (<2 ± 103/mcL) or neutropenia (<1 x 103/mcL), usually found in subjects with aspergillosis. Diagnosis was made on clinical and radiological bases and through BAL cultures, while transbronchial biopsies (performed in 2 cases) resulted aspecific. Therapy with amphotericin-B, infused as directed by the manufacturer (2 cases) or in lipid emulsion (1 case) effected control of the infection (clinical amelioration, reduction of radiologic changes and negativization of control, BAL fluid cultures). Aspergillus infection in HIV-positive patients, even if relatively rare, calls for a wider and prompt recognition and for an aggressive therapeutic approach.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalMediterranean Journal of Infectious and Parasitic Diseases
Volume10
Issue number2
Publication statusPublished - 1995

Keywords

  • amphotericin-B
  • HIV-infection
  • itraconazole
  • lung aspergillosis

ASJC Scopus subject areas

  • Microbiology (medical)

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