Aspirin use and pancreatic cancer risk

Martina Bonifazi, Silvano Gallus, Cristina Bosetti, Jerry Polesel, Diego Serraino, Renato Talamini, Eva Negri, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

Preclinical findings suggest that aspirin might inhibit pancreatic carcinogenesis, but epidemiological data are scanty and controversial. The role of aspirin use in pancreatic cancer is further analyzed in a multicentric hospital-based case-control study conducted in Italy between 1991 and 2008. Cases were 308 patients with incident pancreatic cancer and controls were 477 patients admitted to the same hospitals as cases for acute conditions, not related to risk factors for pancreatic cancer. A total of 22 cases (7%) and 37 controls (8%) reported regular aspirin use, with a corresponding adjusted odds ratio (OR) of 0.87 [95% confidence interval (CI): 0.47-1.61]. A slight protection, although not significant, was observed for duration of use ≥5 years (OR=0.53; 95% CI: 0.21-1.33) and for time since first use ≥10 years (OR=0.69; 95% CI: 0.25-1.93). The risk of pancreatic cancer was significantly below unity for current users of ≥5 years (OR=0.23; 95% CI: 0.06-0.90), but the risk was based on three cases and 16 controls only. We observed no association between regular aspirin use and pancreatic cancer risk, although our results suggested a possible protective effect for long-term current users.

Original languageEnglish
Pages (from-to)352-354
Number of pages3
JournalEuropean Journal of Cancer Prevention
Volume19
Issue number5
DOIs
Publication statusPublished - Sep 2010

Keywords

  • aspirin
  • case-control study
  • pancreatic cancer
  • risk factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Medicine(all)

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