'Aspirinated' platelets are hemostatic in thrombocytopenic rats with 'nonaspirinated' vessel walls - evidence from an exchange transfusion model

E. Dejana, B. Barbieri, G. De Gaetano

Research output: Contribution to journalArticle

Abstract

The contrasting effects of aspirin on bleeding time (BT) might be related to the drug's inhibitory activity on platelets and vascular prostaglandin I2 (PGI2). To test this, we developed an exchange transfusion model in the rat and studied the BT in animals whose platelets but not vessels had been exposed to aspirin. Rats with severe experimental thrombocytopenia were exchange-transfused with blood from normocythemic rats pretreated with aspirin 6 hr before. The platelet count was raised from 2% to about 70% of basel level and the BT returned to control values even though the platelets neither responded to arachidonic acid nor produced detectable amounts of malondialdehyde and vascular PGI2 was not inhibited. These results indicate that 'aspirinated' platelets may be hemostatically active and that the BT is not necessarily affected by unbalanced prostaglandin production in platelets and the vessel wall.

Original languageEnglish
Pages (from-to)954-962
Number of pages9
JournalBlood
Volume56
Issue number6
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Hematology

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