Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group

Fay Betsou, Alexandre Bulla, Sang Yun Cho, Judith Clements, Rodrigo Chuaqui, Domenico Coppola, Yvonne De Souza, Annemieke De Wilde, William Grizzle, Fiorella Guadagni, Elaine Gunter, Stacey Heil, Verity Hodgkinson, Joseph Kessler, Michael Kiehntopf, Hee Sung Kim, Iren Koppandi, Katheryn Shea, Rajeev Singh, Marc SobelStella Somiari, Demetri Spyropoulos, Mars Stone, Gunnel Tybring, Klara Valyi-Nagy, Gert Van Den Eynden, Lalita Wadhwa

Research output: Contribution to journalArticle

Abstract

This technical report presents quality control (QC) assays that can be performed in order to qualify clinical biospecimens that have been biobanked for use in research. Some QC assays are specific to a disease area. Some QC assays are specific to a particular downstream analytical platform. When such a qualification is not possible, QC assays are presented that can be performed to stratify clinical biospecimens according to their biomolecular quality.

Original languageEnglish
Pages (from-to)398-409
Number of pages12
JournalBiopreservation and Biobanking
Volume14
Issue number5
DOIs
Publication statusPublished - Oct 1 2016

Keywords

  • biological fluid
  • biospecimen
  • cells
  • qualification
  • quality control
  • tissue

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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  • Cite this

    Betsou, F., Bulla, A., Cho, S. Y., Clements, J., Chuaqui, R., Coppola, D., De Souza, Y., De Wilde, A., Grizzle, W., Guadagni, F., Gunter, E., Heil, S., Hodgkinson, V., Kessler, J., Kiehntopf, M., Kim, H. S., Koppandi, I., Shea, K., Singh, R., ... Wadhwa, L. (2016). Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group. Biopreservation and Biobanking, 14(5), 398-409. https://doi.org/10.1089/bio.2016.0018