Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)

G. Federico, M. E. Street, M. Maghnie, M. Caruso-Nicoletti, S. Loche, S. Bertelloni, S. Cianfarani, A. Cicognani, S. Loche, M. Maghnie, G. Cesaretti, R. Lorini, F. Meschi, V. de Sanctis, G. Aimarretti, F. Antoniazzi, Teresa Arrigo, Jaele Bellone, Simonetta Bellone, Silvano BertalloniMauro Bozzola, Fabio Buzi, Marco Cappa, Manuela Caruso-Nicoletti, Stefano Cianfarani, Mariangela Cistemino, Filippo De Luca, Maurizio Del Vecchio, Giovanni Federico, Fiorella Galluzzi, Daniela Germani, Paolo Ghirri, Lucia Ghizzoni, Nella Augusta Greggio, Lorenzo Lughetti, Sandro Loche, Stefania Losi, Antonio Luciano, Claudio Maffeis, Mohamad Maghnie, Elisabetta Modestini, Piero Pirazzoli, Gabriella Pozzobon, Barbara Predieri, Roberto Rusconi, Maria Carolina Slerno, Alessandro Salvatoni, Giuseppe Scirè, Salvatore Scommegna, Gian Luigi Spadoni, Maddalena Sposito, Malgorzata Wasniewska, Maria Zampolli, Stefano Zucchini

Research output: Contribution to journalArticlepeer-review

Abstract

The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100%, with a sensitivity ranging from about 70 to 90%. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal childre.

Original languageEnglish
Pages (from-to)732-737
Number of pages6
JournalJournal of Endocrinological Investigation
Volume29
Issue number8
Publication statusPublished - Sep 2006

Keywords

  • Acid-labile subunit
  • GH deficiency
  • GH secretion
  • IGF-binding protein-3
  • IGF-I
  • IGF-II

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)'. Together they form a unique fingerprint.

Cite this