Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)

G. Federico, M. E. Street, M. Maghnie, M. Caruso-Nicoletti, S. Loche, S. Bertelloni, S. Cianfarani, A. Cicognani, S. Loche, M. Maghnie, G. Cesaretti, R. Lorini, F. Meschi, V. de Sanctis, G. Aimarretti, F. Antoniazzi, Teresa Arrigo, Jaele Bellone, Simonetta Bellone, Silvano BertalloniMauro Bozzola, Fabio Buzi, Marco Cappa, Manuela Caruso-Nicoletti, Stefano Cianfarani, Mariangela Cistemino, Filippo De Luca, Maurizio Del Vecchio, Giovanni Federico, Fiorella Galluzzi, Daniela Germani, Paolo Ghirri, Lucia Ghizzoni, Nella Augusta Greggio, Lorenzo Lughetti, Sandro Loche, Stefania Losi, Antonio Luciano, Claudio Maffeis, Mohamad Maghnie, Elisabetta Modestini, Piero Pirazzoli, Gabriella Pozzobon, Barbara Predieri, Roberto Rusconi, Maria Carolina Slerno, Alessandro Salvatoni, Giuseppe Scirè, Salvatore Scommegna, Gian Luigi Spadoni, Maddalena Sposito, Malgorzata Wasniewska, Maria Zampolli, Stefano Zucchini

Research output: Contribution to journalArticle

Abstract

The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100%, with a sensitivity ranging from about 70 to 90%. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal childre.

Original languageEnglish
Pages (from-to)732-737
Number of pages6
JournalJournal of Endocrinological Investigation
Volume29
Issue number8
Publication statusPublished - Sep 2006

Fingerprint

Endocrinology
Insulin-Like Growth Factor I
Pediatrics
Serum
Pituitary Dwarfism
Pharmacology
Growth

Keywords

  • Acid-labile subunit
  • GH deficiency
  • GH secretion
  • IGF-binding protein-3
  • IGF-I
  • IGF-II

ASJC Scopus subject areas

  • Endocrinology

Cite this

Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency : A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED). / Federico, G.; Street, M. E.; Maghnie, M.; Caruso-Nicoletti, M.; Loche, S.; Bertelloni, S.; Cianfarani, S.; Cicognani, A.; Loche, S.; Maghnie, M.; Cesaretti, G.; Lorini, R.; Meschi, F.; de Sanctis, V.; Aimarretti, G.; Antoniazzi, F.; Arrigo, Teresa; Bellone, Jaele; Bellone, Simonetta; Bertalloni, Silvano; Bozzola, Mauro; Buzi, Fabio; Cappa, Marco; Caruso-Nicoletti, Manuela; Cianfarani, Stefano; Cistemino, Mariangela; De Luca, Filippo; Del Vecchio, Maurizio; Federico, Giovanni; Galluzzi, Fiorella; Germani, Daniela; Ghirri, Paolo; Ghizzoni, Lucia; Greggio, Nella Augusta; Lughetti, Lorenzo; Loche, Sandro; Losi, Stefania; Luciano, Antonio; Maffeis, Claudio; Maghnie, Mohamad; Modestini, Elisabetta; Pirazzoli, Piero; Pozzobon, Gabriella; Predieri, Barbara; Rusconi, Roberto; Slerno, Maria Carolina; Salvatoni, Alessandro; Scirè, Giuseppe; Scommegna, Salvatore; Spadoni, Gian Luigi; Sposito, Maddalena; Wasniewska, Malgorzata; Zampolli, Maria; Zucchini, Stefano.

In: Journal of Endocrinological Investigation, Vol. 29, No. 8, 09.2006, p. 732-737.

Research output: Contribution to journalArticle

Federico, G, Street, ME, Maghnie, M, Caruso-Nicoletti, M, Loche, S, Bertelloni, S, Cianfarani, S, Cicognani, A, Loche, S, Maghnie, M, Cesaretti, G, Lorini, R, Meschi, F, de Sanctis, V, Aimarretti, G, Antoniazzi, F, Arrigo, T, Bellone, J, Bellone, S, Bertalloni, S, Bozzola, M, Buzi, F, Cappa, M, Caruso-Nicoletti, M, Cianfarani, S, Cistemino, M, De Luca, F, Del Vecchio, M, Federico, G, Galluzzi, F, Germani, D, Ghirri, P, Ghizzoni, L, Greggio, NA, Lughetti, L, Loche, S, Losi, S, Luciano, A, Maffeis, C, Maghnie, M, Modestini, E, Pirazzoli, P, Pozzobon, G, Predieri, B, Rusconi, R, Slerno, MC, Salvatoni, A, Scirè, G, Scommegna, S, Spadoni, GL, Sposito, M, Wasniewska, M, Zampolli, M & Zucchini, S 2006, 'Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)', Journal of Endocrinological Investigation, vol. 29, no. 8, pp. 732-737.
Federico, G. ; Street, M. E. ; Maghnie, M. ; Caruso-Nicoletti, M. ; Loche, S. ; Bertelloni, S. ; Cianfarani, S. ; Cicognani, A. ; Loche, S. ; Maghnie, M. ; Cesaretti, G. ; Lorini, R. ; Meschi, F. ; de Sanctis, V. ; Aimarretti, G. ; Antoniazzi, F. ; Arrigo, Teresa ; Bellone, Jaele ; Bellone, Simonetta ; Bertalloni, Silvano ; Bozzola, Mauro ; Buzi, Fabio ; Cappa, Marco ; Caruso-Nicoletti, Manuela ; Cianfarani, Stefano ; Cistemino, Mariangela ; De Luca, Filippo ; Del Vecchio, Maurizio ; Federico, Giovanni ; Galluzzi, Fiorella ; Germani, Daniela ; Ghirri, Paolo ; Ghizzoni, Lucia ; Greggio, Nella Augusta ; Lughetti, Lorenzo ; Loche, Sandro ; Losi, Stefania ; Luciano, Antonio ; Maffeis, Claudio ; Maghnie, Mohamad ; Modestini, Elisabetta ; Pirazzoli, Piero ; Pozzobon, Gabriella ; Predieri, Barbara ; Rusconi, Roberto ; Slerno, Maria Carolina ; Salvatoni, Alessandro ; Scirè, Giuseppe ; Scommegna, Salvatore ; Spadoni, Gian Luigi ; Sposito, Maddalena ; Wasniewska, Malgorzata ; Zampolli, Maria ; Zucchini, Stefano. / Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency : A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED). In: Journal of Endocrinological Investigation. 2006 ; Vol. 29, No. 8. pp. 732-737.
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abstract = "The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100{\%}, with a sensitivity ranging from about 70 to 90{\%}. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal childre.",
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author = "G. Federico and Street, {M. E.} and M. Maghnie and M. Caruso-Nicoletti and S. Loche and S. Bertelloni and S. Cianfarani and A. Cicognani and S. Loche and M. Maghnie and G. Cesaretti and R. Lorini and F. Meschi and {de Sanctis}, V. and G. Aimarretti and F. Antoniazzi and Teresa Arrigo and Jaele Bellone and Simonetta Bellone and Silvano Bertalloni and Mauro Bozzola and Fabio Buzi and Marco Cappa and Manuela Caruso-Nicoletti and Stefano Cianfarani and Mariangela Cistemino and {De Luca}, Filippo and {Del Vecchio}, Maurizio and Giovanni Federico and Fiorella Galluzzi and Daniela Germani and Paolo Ghirri and Lucia Ghizzoni and Greggio, {Nella Augusta} and Lorenzo Lughetti and Sandro Loche and Stefania Losi and Antonio Luciano and Claudio Maffeis and Mohamad Maghnie and Elisabetta Modestini and Piero Pirazzoli and Gabriella Pozzobon and Barbara Predieri and Roberto Rusconi and Slerno, {Maria Carolina} and Alessandro Salvatoni and Giuseppe Scir{\`e} and Salvatore Scommegna and Spadoni, {Gian Luigi} and Maddalena Sposito and Malgorzata Wasniewska and Maria Zampolli and Stefano Zucchini",
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TY - JOUR

T1 - Assesment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency

T2 - A proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED)

AU - Federico, G.

AU - Street, M. E.

AU - Maghnie, M.

AU - Caruso-Nicoletti, M.

AU - Loche, S.

AU - Bertelloni, S.

AU - Cianfarani, S.

AU - Cicognani, A.

AU - Loche, S.

AU - Maghnie, M.

AU - Cesaretti, G.

AU - Lorini, R.

AU - Meschi, F.

AU - de Sanctis, V.

AU - Aimarretti, G.

AU - Antoniazzi, F.

AU - Arrigo, Teresa

AU - Bellone, Jaele

AU - Bellone, Simonetta

AU - Bertalloni, Silvano

AU - Bozzola, Mauro

AU - Buzi, Fabio

AU - Cappa, Marco

AU - Caruso-Nicoletti, Manuela

AU - Cianfarani, Stefano

AU - Cistemino, Mariangela

AU - De Luca, Filippo

AU - Del Vecchio, Maurizio

AU - Federico, Giovanni

AU - Galluzzi, Fiorella

AU - Germani, Daniela

AU - Ghirri, Paolo

AU - Ghizzoni, Lucia

AU - Greggio, Nella Augusta

AU - Lughetti, Lorenzo

AU - Loche, Sandro

AU - Losi, Stefania

AU - Luciano, Antonio

AU - Maffeis, Claudio

AU - Maghnie, Mohamad

AU - Modestini, Elisabetta

AU - Pirazzoli, Piero

AU - Pozzobon, Gabriella

AU - Predieri, Barbara

AU - Rusconi, Roberto

AU - Slerno, Maria Carolina

AU - Salvatoni, Alessandro

AU - Scirè, Giuseppe

AU - Scommegna, Salvatore

AU - Spadoni, Gian Luigi

AU - Sposito, Maddalena

AU - Wasniewska, Malgorzata

AU - Zampolli, Maria

AU - Zucchini, Stefano

PY - 2006/9

Y1 - 2006/9

N2 - The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100%, with a sensitivity ranging from about 70 to 90%. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal childre.

AB - The diagnosis of GH deficiency (GHD) is based on the measurement of peak GH responses to pharmacological stimuli. Pharmacological stimuli, however, lack precision, accuracy, are not reproducible, are invasive, non-physiological and some may even be hazardous. Furthermore, different GH commercial assays used to measure GH in serum yield results that may differ considerably. In contrast to GH, IGF-I can be measured on a single, randomly-obtained blood sample. A review of the available data indicates that IGF-I measurement in the diagnosis of childhood-onset isolated GHD has a specificity of up to 100%, with a sensitivity ranging from about 70 to 90%. We suggest an algorithm in which circulating levels of IGF-I together with the evaluation of auxological data, such as growth rate and growth, may be used to assess the likelihood of GHD in pre-pubertal childre.

KW - Acid-labile subunit

KW - GH deficiency

KW - GH secretion

KW - IGF-binding protein-3

KW - IGF-I

KW - IGF-II

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