Assessing attention and cognitive function in completely locked-in state with event-related brain potentials and epidural electrocorticography

Michael Bensch, Suzanne Martens, Sebastian Halder, Jeremy Hill, Femke Nijboer, Ander Ramos, Niels Birbaumer, Martin Bogdan, Boris Kotchoubey, Wolfgang Rosenstiel, Bernhard Schölkopf, Alireza Gharabaghi

Research output: Contribution to journalArticle

Abstract

Objective. Patients in the completely locked-in state (CLIS), due to, for example, amyotrophic lateral sclerosis (ALS), no longer possess voluntary muscle control. Assessing attention and cognitive function in these patients during the course of the disease is a challenging but essential task for both nursing staff and physicians. Approach. An electrophysiological cognition test battery, including auditory and semantic stimuli, was applied in a late-stage ALS patient at four different time points during a six-month epidural electrocorticography (ECoG) recording period. Event-related cortical potentials (ERP), together with changes in the ECoG signal spectrum, were recorded via 128 channels that partially covered the left frontal, temporal and parietal cortex. Main results. Auditory but not semantic stimuli induced significant and reproducible ERP projecting to specific temporal and parietal cortical areas. N1/P2 responses could be detected throughout the whole study period. The highest P3 ERP was measured immediately after the patient's last communication through voluntary muscle control, which was paralleled by low theta and high gamma spectral power. Three months after the patient's last communication, i.e., in the CLIS, P3 responses could no longer be detected. At the same time, increased activity in low-frequency bands and a sharp drop of gamma spectral power were recorded. Significance. Cortical electrophysiological measures indicate at least partially intact attention and cognitive function during sparse volitional motor control for communication. Although the P3 ERP and frequency-specific changes in the ECoG spectrum may serve as indicators for CLIS, a close-meshed monitoring will be required to define the exact time point of the transition.

Original languageEnglish
Article number026006
JournalJournal of Neural Engineering
Volume11
Issue number2
DOIs
Publication statusPublished - 2014

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Evoked Potentials
Cognition
Brain
Muscle
Communication
P300 Event-Related Potentials
Semantics
Amyotrophic Lateral Sclerosis
Nursing
Skeletal Muscle
Frequency bands
Parietal Lobe
Nursing Staff
Frontal Lobe
Temporal Lobe
Monitoring
Electrocorticography
Physicians
Power (Psychology)

Keywords

  • amyotrophic lateral sclerosis
  • cognition detection
  • electrocorticography
  • epidural recording
  • evoked potentials
  • locked-in state
  • MMN
  • P3

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Assessing attention and cognitive function in completely locked-in state with event-related brain potentials and epidural electrocorticography. / Bensch, Michael; Martens, Suzanne; Halder, Sebastian; Hill, Jeremy; Nijboer, Femke; Ramos, Ander; Birbaumer, Niels; Bogdan, Martin; Kotchoubey, Boris; Rosenstiel, Wolfgang; Schölkopf, Bernhard; Gharabaghi, Alireza.

In: Journal of Neural Engineering, Vol. 11, No. 2, 026006, 2014.

Research output: Contribution to journalArticle

Bensch, M, Martens, S, Halder, S, Hill, J, Nijboer, F, Ramos, A, Birbaumer, N, Bogdan, M, Kotchoubey, B, Rosenstiel, W, Schölkopf, B & Gharabaghi, A 2014, 'Assessing attention and cognitive function in completely locked-in state with event-related brain potentials and epidural electrocorticography', Journal of Neural Engineering, vol. 11, no. 2, 026006. https://doi.org/10.1088/1741-2560/11/2/026006
Bensch, Michael ; Martens, Suzanne ; Halder, Sebastian ; Hill, Jeremy ; Nijboer, Femke ; Ramos, Ander ; Birbaumer, Niels ; Bogdan, Martin ; Kotchoubey, Boris ; Rosenstiel, Wolfgang ; Schölkopf, Bernhard ; Gharabaghi, Alireza. / Assessing attention and cognitive function in completely locked-in state with event-related brain potentials and epidural electrocorticography. In: Journal of Neural Engineering. 2014 ; Vol. 11, No. 2.
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