Assessing corpus callosum changes in Alzheimer's disease: Comparison between tract-based spatial statistics and atlas-based tractography

Maria Giulia Preti, Francesca Baglio, Maria Marcella Laganà, Ludovica Griffanti, Raffaello Nemni, Mario Clerici, Marco Bozzali, Giuseppe Baselli

Research output: Contribution to journalArticle

Abstract

Tractography based on Diffusion Tensor Imaging (DTI) represents a valuable tool for investigating brain white matter (WM) microstructure, allowing the computation of damage-related diffusion parameters such as Fractional Anisotropy (FA) in specific WM tracts. This technique appears relevant in the study of pathologies in which brain disconnection plays a major role, such as, for instance, Alzheimer's Disease (AD). Previous DTI studies have reported inconsistent results in defining WM abnormalities in AD and in its prodromal stage (i.e., amnestic Mild Cognitive Impairment; aMCI), especially when investigating the corpus callosum (CC). A reason for these inconsistencies is the use of different processing techniques, which may strongly influence the results. The aim of the current study was to compare a novel atlas-based tractography approach, that sub-divides the CC in eight portions, with Tract-Based Spatial Statistics (TBSS) when used to detect specific patterns of CC FA in AD at different clinical stages. FA data were obtained from 76 subjects (37 with mild AD, 19 with aMCI and 20 elderly healthy controls, HC) and analyzed using both methods. Consistent results were obtained for the two methods, concerning the comparisons AD vs. HC (significantly reduced FA in the whole CC of AD patients) and AD vs. aMCI (significantly reduced FA in the frontal portions of the CC in AD patients), thus identifying a relative preservation of the frontal CC regions in aMCI patients compared to AD. Conversely, the atlas-based method but not the TBSS showed the ability to detect a selective FA change in the CC parietal, left temporal and occipital regions of aMCI patients compared to HC. This finding indicates that an analysis including a higher number of voxels (with no restriction to tract skeletons) may detect characteristic pattern of FA in the CC of patients with preclinical AD, when brain atrophy is still modest.

Original languageEnglish
Article numbere35856
JournalPLoS One
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 24 2012

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Atlases
Corpus Callosum
Alzheimer disease
Alzheimer Disease
statistics
Anisotropy
Statistics
Diffusion tensor imaging
Brain
Diffusion Tensor Imaging
brain
image analysis
Prodromal Symptoms
Occipital Lobe
methodology
Aptitude
Pathology
Temporal Lobe
atrophy
Skeleton

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Assessing corpus callosum changes in Alzheimer's disease : Comparison between tract-based spatial statistics and atlas-based tractography. / Preti, Maria Giulia; Baglio, Francesca; Laganà, Maria Marcella; Griffanti, Ludovica; Nemni, Raffaello; Clerici, Mario; Bozzali, Marco; Baselli, Giuseppe.

In: PLoS One, Vol. 7, No. 4, e35856, 24.04.2012.

Research output: Contribution to journalArticle

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