Assessing effects of neurotoxic pollutants by biochemical markers

Luigi Manzo, Anna F. Castoldi, Teresa Coccini, Leon D. Prockop

Research output: Contribution to journalArticle

Abstract

Neurotoxins cause biochemical and molecular events which indicate early stage effects in exposed persons well before or well below the induction of overt disease. Monitoring these early events may represent a valid approach to developing markers of neurotoxicity in individuals exposed to environmental chemicals. In neurotoxicology, the use of biochemical markers is more problematic compared to other fields due to the complexity of central nervous system function, the multistage nature of neurotoxic events, and the inaccessibility of target tissue. Nevertheless, new biochemical assays have been developed in recent years to assess exposure, subclinical effects, and susceptibility to neurotoxic disorders. This paper reviews novel biomarkers of neurotoxicity and discusses perspectives and limitations of their use in occupational and environmental medicine.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalEnvironmental Research
Volume85
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Biomarkers
  • Neurotoxicity
  • Pollutants

ASJC Scopus subject areas

  • Environmental Science(all)

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