Assessing grip strength in healthy individuals and patients with immune-mediated polyneuropathies

I. S J Merkies, P. I M Schmitz, J. P A Samijn, F. G A Van Der Mech, K. V. Toyka, P. A. Van Doorn, J. Aubry, N. Baumann, [No Value] Bouche, G. Comi, M. C. Dalakas, H. P. Hartung, R. A C Hughes, I. Illa, M. R J Knapp, J. M. Lger, R. Nemni, E. Nobile-Orazio, K. V. Toyka, P. Van De BerghF. G A Van Der Mech, P. A. Van Doorn, H. J. Willison, B. Younes-Chennoufi

Research output: Contribution to journalArticlepeer-review

Abstract

Grip strength reference values for a portable dynamometer, the hand-held Vigorimeter, were calculated, and its validity, reliability, and responsiveness were examined in patients with immune-mediated polyneuropathies. We studied 530 healthy controls (age 5-93 years), 113 patients with stable polyneuropathy (83 with Guillain-Barre syndrome [GBS], 22 with chronic inflammatory demyelinating polyneuropathy [CIDP], and 8 with a gammopathy-associated polyneuropathy), and 20 patients with GBS or CIDP and changing clinical conditions (longitudinal group). An arm-disability scale was also assessed. Grip-strength reference values were calculated depending primarily on age and gender. Significant association was obtained between the Vigorimeter and the arm scale (in stable group, Spearman rank: r = -0.52 to -0.62; P ≤ 0.0005; in longitudinal group, linear regressions: r = 0.62-0.64, P <0.0001). Good interobserver and intraobserver agreements (analysis of variance, r = 0.95-0.97) and high responsiveness (standardized response mean scores ≥ 0.8) were demonstrated for the Vigorimeter. These results emphasize the clinical usefulness of the Vigorimeter, particularly in patients with immune-mediated polyneuropathies. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish
Pages (from-to)1393-1401
Number of pages9
JournalMuscle and Nerve
Volume23
Issue number9
DOIs
Publication statusPublished - 2000

Keywords

  • Grip strength
  • Immune-mediated polyneuropathies
  • Reference values
  • Reliability
  • Responsiveness
  • Validity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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