TY - JOUR
T1 - Assessing response, remission and treatment resistance in patients with Obsessive-Compulsive Disorder with and without Tic Disorders
T2 - Results from a multicenter study
AU - Benatti, Beatrice
AU - Girone, Nicolaja
AU - Conti, Dario
AU - Cafaro, Rita
AU - Viganò, Caterina
AU - Briguglio, Matteo
AU - Marazziti, Donatella
AU - Mucci, Federico
AU - Gambini, Orsola
AU - De Martini, Benedetta
AU - Tundo, Antonio
AU - Necci, Roberta
AU - De Berardis, Domenico
AU - Galentino, Roberta
AU - De Michele, Sara
AU - Balestrino, Roberta
AU - Albert, Umberto
AU - Rigardetto, Sylvia
AU - Mania, Giuseppe
AU - Grassi, Giacomo
AU - Pallanti, Stefano
AU - Amerio, Andrea
AU - Aguglia, Andrea
AU - Prestia, Davide
AU - Amore, Mario
AU - Priori, Alberto
AU - Servello, Domenico
AU - Porta, Mauro
AU - Dell'Osso, Bernardo
N1 - Publisher Copyright:
© 2021 Cambridge University Press. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Objective Highlighting the relationship between Obsessive Compulsive Disorder (OCD) and Tic Disorder (TD), two highly disabling, comorbid and difficult-to-treat conditions, DSM-5 acknowledged a new "tic-related" specifier for OCD, i.e., Obsessive-Compulsive Tic-related Disorder (OCTD). As patients with OCTD may frequently show poor treatment response, the aim of this multicentre study was to investigate rates and clinical correlates of response, remission and treatment resistance in a large multicentre sample of OCD patients with versus without tics. Methods A sample of 398 patients with a DSM-5 diagnosis of OCD with and without comorbid TD was assessed from ten different psychiatric departments across Italy. For the purpose of the study, treatment response profiles in the whole sample were analysed comparing the rates of response, remission and treatment-resistance as well as related clinical features. Multivariate logistic regressions were performed to identify possible factors associated with treatment response. Results The remission group was associated with later ages of onset of TD and OCD. Moreover, significantly higher rates of psychiatric comorbidities, TD, and lifetime suicidal ideation and attempts emerged in the treatment-resistant group, with larger degrees of perceived worsened quality of life and family involvement.
AB - Objective Highlighting the relationship between Obsessive Compulsive Disorder (OCD) and Tic Disorder (TD), two highly disabling, comorbid and difficult-to-treat conditions, DSM-5 acknowledged a new "tic-related" specifier for OCD, i.e., Obsessive-Compulsive Tic-related Disorder (OCTD). As patients with OCTD may frequently show poor treatment response, the aim of this multicentre study was to investigate rates and clinical correlates of response, remission and treatment resistance in a large multicentre sample of OCD patients with versus without tics. Methods A sample of 398 patients with a DSM-5 diagnosis of OCD with and without comorbid TD was assessed from ten different psychiatric departments across Italy. For the purpose of the study, treatment response profiles in the whole sample were analysed comparing the rates of response, remission and treatment-resistance as well as related clinical features. Multivariate logistic regressions were performed to identify possible factors associated with treatment response. Results The remission group was associated with later ages of onset of TD and OCD. Moreover, significantly higher rates of psychiatric comorbidities, TD, and lifetime suicidal ideation and attempts emerged in the treatment-resistant group, with larger degrees of perceived worsened quality of life and family involvement.
KW - Obsessive compulsive disorder
KW - Psychopharmacology
KW - Remission
KW - Response
KW - Tic disorder
KW - Treatment resistance
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U2 - 10.1017/S109285292100081X
DO - 10.1017/S109285292100081X
M3 - Article
AN - SCOPUS:85115985287
JO - CNS Spectrums
JF - CNS Spectrums
SN - 1092-8529
ER -