Assessing the Correlation between Grey and White Matter Damage with Motor and Cognitive Impairment in Multiple Sclerosis Patients

Emilia Sbardella, Nikolaos Petsas, Francesca Tona, Luca Prosperini, Eytan Raz, Gianvito Pace, Carlo Pozzilli, Patrizia Pantano

Research output: Contribution to journalArticle

Abstract

Background: Multiple sclerosis (MS) is characterized by demyelinating and degenerative processes within the central nervous system. Unlike conventional MRI,new advanced imaging techniques improve pathological specificity and better highlight the relationship between anatomical damage and clinical impairment. Objective: To investigate the relationship between clinical disability and both grey (GM) and white matter (WM) regional damage in MS patients. Methods: Thirty-six relapsing remitting-MS patients and 25 sex- and age-matched controls were enrolled. All patients were clinically evaluated by the Expanded Disability Status Scale and the Multiple Sclerosis Functional Composite (MSFC) scale, which includes the 9-hole peg test (9HPT), the timed 25-feet walking test (T25FW) and the paced auditory serial addition test (PASAT). All subjects were imaged by a 3.0 T scanner: dual-echo fast spin-echo, 3DT1-weighted and diffusion-tensor imaging (DTI) sequences were acquired. Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analyses were run for regional GM and WM assessment, respectively. T2 lesion volumes were also calculated, by using a semi-automated technique. Results: Brain volumetric assessment of GM and DTI measures revealed significant differences between patients and controls. In patients, different measures of WM damage correlated each-other (p

Original languageEnglish
Article numbere63250
JournalPLoS One
Volume8
Issue number5
DOIs
Publication statusPublished - May 16 2013

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Diffusion tensor imaging
sclerosis
Multiple Sclerosis
Neurology
Diffusion Tensor Imaging
Magnetic resonance imaging
image analysis
Brain
Statistics
Imaging techniques
Composite materials
Relapsing-Remitting Multiple Sclerosis
Spatial Analysis
testing
scanners
morphometry
lesions (animal)
walking
Walking
central nervous system

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Assessing the Correlation between Grey and White Matter Damage with Motor and Cognitive Impairment in Multiple Sclerosis Patients. / Sbardella, Emilia; Petsas, Nikolaos; Tona, Francesca; Prosperini, Luca; Raz, Eytan; Pace, Gianvito; Pozzilli, Carlo; Pantano, Patrizia.

In: PLoS One, Vol. 8, No. 5, e63250, 16.05.2013.

Research output: Contribution to journalArticle

Sbardella, Emilia ; Petsas, Nikolaos ; Tona, Francesca ; Prosperini, Luca ; Raz, Eytan ; Pace, Gianvito ; Pozzilli, Carlo ; Pantano, Patrizia. / Assessing the Correlation between Grey and White Matter Damage with Motor and Cognitive Impairment in Multiple Sclerosis Patients. In: PLoS One. 2013 ; Vol. 8, No. 5.
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