Abstract
Original language | English |
---|---|
Pages (from-to) | 940-958 |
Number of pages | 19 |
Journal | Physiological Measurement |
Volume | 38 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- aging
- autonomic nervous system
- cardiovascular control
- heart rate variability
- interaction information
- multivariate linear regression model
- transfer entropy decomposition
- adult
- aged
- arterial pressure
- biological model
- breathing
- heart rate
- human
- middle aged
- normal human
- physiology
- systole
- young adult
- Adult
- Aged
- Aging
- Arterial Pressure
- Healthy Volunteers
- Heart Rate
- Humans
- Middle Aged
- Models, Cardiovascular
- Respiration
- Systole
- Young Adult
Fingerprint
Dive into the research topics of 'Assessing the evolution of redundancy/synergy of spontaneous variability regulation with age'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Assessing the evolution of redundancy/synergy of spontaneous variability regulation with age. / Porta, A.; Bari, V.; De Maria, B. et al.
In: Physiological Measurement, Vol. 38, No. 5, 2017, p. 940-958.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Assessing the evolution of redundancy/synergy of spontaneous variability regulation with age
AU - Porta, A.
AU - Bari, V.
AU - De Maria, B.
AU - Perseguini, N.M.
AU - Milan, J.
AU - Rehder-Santos, P.
AU - Minatel, V.
AU - Takahashi, A.C.M.
AU - Catai, A.M.
N1 - Cited By :1 Export Date: 2 March 2018 CODEN: PMEAE Correspondence Address: Porta, A.; Dipartimento di Scienze Biomediche per la Salute, Universit degli Studi di Milano, IRCCS Policlinico San Donato, Laboratorio di Modellistica di Sistemi Complessi, Via F. Fellini 4, Italy; email: alberto.porta@unimi.it References: Akaike, H., A new look at the statistical novel identification (1974) IEEE Trans. Autom. Control, 19, pp. 716-723; Andrzejak, R.G., Kraskov, A., Stogbauer, H., Mormann, F., Kreuz, T., Bivariate surrogate techniques: Necessity, strengths, and caveats (2003) Phys. Rev., 68; Barnett, L., Barrett, A.B., Seth, A.K., Granger causality and transfer entropy are equivalent for Gaussian variables (2009) Phys. Rev. Lett., 103; Barrett, A.B., Exploration of synergistic and redundant information sharing in static and dynamical Gaussian systems (2015) Phys. Rev., 91; Baselli, G., Cerutti, S., Badilini, F., Biancardi, L., Porta, A., Pagani, M., Lombardi, F., Malliani, A., Model for the assessment of heart period and arterial pressure variability interactions and respiratory influences (1994) Med. Biol. Eng. Comput., 32, pp. 143-152; Baselli, G., Porta, A., Pagani, M., Coupling arterial windkessel with peripheral vasomotion: Modeling the effects on low-frequency oscillations (2006) IEEE Trans. Biomed. Eng., 53, pp. 53-64; Baselli, G., Porta, A., Rimoldi, O., Pagani, M., Cerutti, S., Spectral decomposition in multichannel recordings based on multivariate parametric identification (1997) IEEE Trans. Biomed. Eng., 44, pp. 1092-1101; Beckers, F., Verheyden, B., Aubert, A.E., Aging and nonlinear heart rate control in a healthy population (2006) Am. J. Physiol., 290, pp. H2560-H2570; Caiani, E., Turiel, M., Muzzupappa, S., Porta, A., Baselli, G., Pagani, M., Cerutti, S., Malliani, A., Evaluation of respiratory influences on left ventricular function parameters extracted from echocardiographic acoustic quantification (2000) Physiol. Meas., 21 (1), pp. 175-186; Catai, A.M., Takahashi, A.C.M., Perseguini, N.M., Milan, J., Minatel, V., Rehder-Santos, P., Marchi, A., Porta, A., Effect of the postural challenge on the dependence of the cardiovascular control complexity on age (2014) Entropy, 16, pp. 6686-6704; Cohen, M.A., Taylor, J.A., Short-term cardiovascular oscillations in man: Measuring and modelling the physiologies (2002) J. Physiol., 542, pp. 669-683; Cooke, W.H., Hoag, J.B., Crossman, A.A., Kuusela, T.A., Tahvanainen, K.U.O., Eckberg, D.L., Human responses to upright tilt: A window on central autonomic integration (1999) J. Physiol., 517, pp. 617-628; De Boer, R.W., Karemaker, J.M., Strackee, J., Hemodynamic fluctuations and baroreflex sensitivity in humans: A beat-to-beat model (1987) Am. J. Physiol., 253, pp. H680-H689; Dick, T.E., Baekey, D.M., Paton, J.F.R., Lindsey, B.G., Morris, K.F., Cardiorespiratory coupling depends on the pons (2009) Resp. Physiol. Neurobiol., 168, pp. 78-85; Eckberg, D.L., The human respiratory gate (2003) J. Physiol., 548, pp. 339-352; Eckberg, D.L., Temporal response patterns of the human sinus node to brief carotid baroreceptor stimuli (1976) J. Physiol., 258, pp. 769-782; Elstad, M., Walloe, L., Heart rate variability and stroke volume variability to detect central hypovolemia during spontaneous breathing and supported ventilation in young, healthy volunteers (2015) Physiol. Meas., 36 (4), pp. 671-681; Faes, L., Porta, A., Nollo, G., Redundant and synergistic information transfer in cardiovascular and cardiorespiratory variability (2015) Proc. of the 37th Annual Int. Conf. of the IEEE EMBS, pp. 4033-4036; Faes, L., Porta, A., Rossato, G., Adami, A., Tonon, D., Corica, A., Nollo, G., Investigating the mechanisms of cardiovascular and cerebrovascular regulation in orthostatic syncope through an information decomposition strategy (2013) Autonom. Neurosci.: Basic Clin., 178, pp. 76-82; Furlan, R., Porta, A., Costa, F., Tank, J., Baker, L., Schiavi, R., Robertson, D., Mosqueda-Garcia, R., Oscillatory patterns in sympathetic neural discharge and cardiovascular variables during orthostatic stimulus (2000) Circulation, 101, pp. 886-892; Granger, C.W.J., Testing for causality. A personal viewpoint (1980) J. Econ. Dyn. Control, 2, pp. 329-352; Guyenet, P.G., The sympathetic control of blood pressure (2006) Nat. Rev. Neurosci., 7, pp. 335-346; Hlavackova-Schindler, K., Palus, M., Vejmelka, M., Bhattacharya, J., Causality detection based on information-theoretic approaches in time series analysis (2007) Phys. Rep., 441, pp. 1-46; Iatsenko, D., Bernjak, A., Stankovski, T., Shiogai, Y., Owen-Lynch, P.J., Clarkson, P.B.M., McClintock, P.V.E., Stefanovska, A., Evolution of cardiorespiratory interactions with age (2013) Phil. Trans. R. Soc., 371, p. 20110622; Kelly, J., O'Malley, K., Adrenoceptor function and ageing (1984) Clin. Sci., 66, pp. 509-515; Laitinen, T., Niskamen, L., Geelen, G., Lansimies, E., Hartikainen, J., Age dependency of cardiovascular autonomic responses to head-up tilt in healthy subjects (2004) J. Appl. Physiol., 96, pp. 2333-2340; Lakatta, E.G., Cardiovascular regulatory mechanisms in advanced age (1993) Physiol Rev., 73, pp. 413-465; Lakatta, E.G., Levy, D., Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part II: The aging heart in health: Links to heart disease (2003) Circulation, 107, pp. 346-354. , 2003a; Lakatta, E.G., Levy, D., Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part I: Aging arteries: A 'set up' for vascular disease (2003) Circulation, 107, pp. 139-146. , 2003b; Larson, E.D., St Clair, J.R., Summer, W.A., Bannister, R.A., Proenza, C., Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate (2013) Proc. Natl Acad. Sci. USA, 110, pp. 18011-18016; Marchi, A., Bari, V., De Maria, B., Esler, M., Lambert, E., Baumert, M., Porta, A., Calibrated variability of muscle sympathetic nerve activity during graded head-up tilt in humans and its link with noradrenaline data and cardiovascular rhythms (2016) Am. J. Physiol., 310, pp. R1134-R1143. , 2016a; Marchi, A., Bari, V., De Maria, B., Esler, M., Lambert, E., Baumert, M., Porta, A., Simultaneous characterization of sympathetic and cardiac arms of the baroreflex through sequence techniques during incremental head-up tilt (2016) Front. Physiol., 7, p. 438. , 2016b; Magagnin, V., Bassani, T., Bari, V., Turiel, M., Maestri, R., Pinna, G.D., Porta, A., Non-stationarities significantly distort short-term spectral, symbolic and entropy heart rate variability indexes (2011) Physiol. Meas., 32 (11), pp. 1775-1786; Montano, N., Gnecchi-Ruscone, T., Porta, A., Lombardi, F., Pagani, M., Malliani, A., Power spectrum analysis of heart rate variability to assess changes in sympatho-vagal balance during graded orthostatic tilt (1994) Circulation, 90, pp. 1826-1831; Nemati, S., Edwards, B.A., Lee, J., Pittman-Polletta, B., Butler, J.P., Malhotra, A., Respiration and heart rate complexity: Effects of age and gender assessed by band-limited transfer entropy (2013) Resp. Physiol. Neurobiol., 189, pp. 27-33; Nilsson, H., Aalkjaer, C., Vasomotion: Mechanisms and physiological importance (2003) Mol. Interv., 3, pp. 79-89; Nollo, G., Faes, L., Porta, A., Antolini, R., Ravelli, F., Exploring directionality in spontaneous heart period and systolic pressure variability interactions in humans: Implications in the evaluation of baroreflex gain (2005) Am. J. Physiol., 288, pp. H1777-H1785; Nollo, G., Faes, L., Porta, A., Pellegrini, B., Ravelli, F., Del Greco, M., Disertori, M., Antolini, R., Evidence of unbalanced regulatory mechanism of heart rate and systolic pressure after acute myocardial infarction (2002) Am. J. Physiol., 283, pp. H1200-H1207; Pagani, M., Montano, N., Porta, A., Malliani, A., Abboud, F.M., Birkett, C., Somers, V.K., Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans (1997) Circulation, 95, pp. 1441-1448; Parker Jones, P., Christou, D.D., Jordan, J., Seals, D.R., Baroreflex buffering is reduced with age in healthy men (2003) Circulation, 107, pp. 1770-1774; Porta, A., Bari, V., Marchi, A., De Maria, B., Takahashi, A.C.M., Guzzetti, S., Colombo, R., Raimondi, F., Effect of variations of the complexity of the target variable on the assessment of Wiener-Granger causality in cardiovascular control studies (2016) Physiol. Meas., 37 (2), pp. 276-290. , 2016a; Porta, A., Bassani, T., Bari, V., Tobaldini, E., Takahashi, A.C., Catai, A.M., Montano, N., Model-based assessment of baroreflex and cardiopulmonary couplings during graded head-up tilt (2012) Comput. Biol. Med., 42, pp. 298-305; Porta, A., Catai, A.M., Takahashi, A.C.M., Magagnin, V., Bassani, T., Tobaldini, E., Van De Borne, P., Montano, N., Causal relationships between heart period and systolic arterial pressure during graded head-up tilt (2011) Am. J. Physiol., 300, pp. R378-R386; Porta, A., Castiglioni, P., Di Rienzo, M., Bassani, T., Bari, V., Faes, L., Nollo, G., Quintin, L., Cardiovascular control and time domain Granger causality: Insights from selective autonomic blockade (2013) Phil. Trans R. Soc., 371, p. 20120161; Porta, A., Faes, L., Wiener-Granger causality in network physiology with applications to cardiovascular control and neuroscience (2016) Proc. IEEE, 104, pp. 282-309. , 2016b; Porta, A., Effect of age on complexity and causality of the cardiovascular control: Comparison between model-based and model-free approaches (2014) PLoS One, 9; Porta, A., Faes, L., Marchi, A., Bari, V., De Maria, B., Guzzetti, S., Colombo, R., Raimondi, F., Disentangling cardiovascular control mechanisms during head-down tilt via joint transfer entropy and self-entropy decompositions (2015) Front. Physiol., 6, p. 301. , 2015a; Porta, A., Faes, L., Nollo, G., Bari, V., Marchi, A., De Maria, B., Takahashi, A.C.M., Catai, A.M., Conditional self-entropy and conditional joint transfer entropy in heart period variability during graded postural challenge (2015) PLoS One, 10, p. e0132851. , 2015b; Porta, A., Tobaldini, E., Guzzetti, S., Furlan, R., Montano, N., Gnecchi-Ruscone, T., Assessment of cardiac autonomic modulation during graded head-up tilt by symbolic analysis of heart rate variability (2007) Am. J. Physiol., 293, pp. H702-H708; Seals, D.R., Esler, M.D., Human ageing and sympathoadrenal system (2000) J. Physiol., 528, pp. 407-417; Söderström, T., Stoica, P., (1989) System Identification, , (Englewood Cliffs, NJ: Prentice Hall); Stramaglia, S., Wu, G.-R., Pellicoro, M., Marinazzo, D., Expanding the transfer entropy to identify information circuits in complex systems (2012) Phys. Rev., 86; Heart rate variability - Standards of measurement, physiological interpretation and clinical use (1996) Circulation, 93, pp. 1043-1065; Timme, N., Alford, W., Flecker, B., Beggs, J.M., Synergy, redundancy, and multivariate information measures: An experimentalist's perspective (2014) J. Comput. Neurosci., 36, pp. 119-140; Turianikova, Z., Javorka, K., Baumert, M., Calkovska, A., Javorka, M., The effect of orthostatic stress on multiscale entropy of heart rate and blood pressure (2011) Physiol. Meas., 32 (9), pp. 1425-1437; Wibral, M., Rahm, B., Rieder, M., Lindner, M., Vicente, R., Kaiser, J., Transfer entropy in magnetoencephalographic data: Quantifying information flow in cortical and cerebellar networks (2011) Prog. Biophys. Mol. Biol., 105, pp. 80-97
PY - 2017
Y1 - 2017
N2 - Objective: We exploited a model-based Wiener-Granger causality method in the information domain for the evaluation of the transfer entropy (TE) and interaction TE (ITE), the latter taken as a measure of the net balance between redundancy and synergy, to describe the interactions between the spontaneous variability of heart period (HP) and systolic arterial pressure (SAP) and the effect of respiration (R) on both variables. Approach: Cardiac control was typified via the genuine TE from SAP to HP, that from R to HP, and the ITE from SAP and R to HP, while vascular control was characterized via the genuine TE from HP to SAP, that from R to SAP, and the ITE from HP and R to SAP. The approach was applied to study age-related modifications of cardiac and vascular controls in a cohort of 100 healthy humans (age from 21 to 70 years, 54 males) recorded at supine rest (REST) and during active standing (STAND). A surrogate approach was exploited to test the significance of the computed quantities. Main results: Trends of the genuine information transfer with age, already present in literature, were here confirmed. We originally found that: (i) at REST redundancy was predominant over synergy in both vascular and cardiac controls; (ii) the predominance of redundancy of the cardiac control was not affected by postural challenge, while STAND reduced redundancy of vascular control; (iii) the net redundancy of the cardiac control at REST gradually decreased with age, while that of vascular control remained stable; (iv) during STAND net redundancy of both cardiac and vascular controls was stable with age. Significance: The study confirms the relevance of computing genuine information transfer in cardiovascular control analysis and stresses the importance of evaluating the ITE to quantify the degree of redundancy of physiological mechanisms operating to maintain cardiovascular homeostasis. © 2017 Institute of Physics and Engineering in Medicine.
AB - Objective: We exploited a model-based Wiener-Granger causality method in the information domain for the evaluation of the transfer entropy (TE) and interaction TE (ITE), the latter taken as a measure of the net balance between redundancy and synergy, to describe the interactions between the spontaneous variability of heart period (HP) and systolic arterial pressure (SAP) and the effect of respiration (R) on both variables. Approach: Cardiac control was typified via the genuine TE from SAP to HP, that from R to HP, and the ITE from SAP and R to HP, while vascular control was characterized via the genuine TE from HP to SAP, that from R to SAP, and the ITE from HP and R to SAP. The approach was applied to study age-related modifications of cardiac and vascular controls in a cohort of 100 healthy humans (age from 21 to 70 years, 54 males) recorded at supine rest (REST) and during active standing (STAND). A surrogate approach was exploited to test the significance of the computed quantities. Main results: Trends of the genuine information transfer with age, already present in literature, were here confirmed. We originally found that: (i) at REST redundancy was predominant over synergy in both vascular and cardiac controls; (ii) the predominance of redundancy of the cardiac control was not affected by postural challenge, while STAND reduced redundancy of vascular control; (iii) the net redundancy of the cardiac control at REST gradually decreased with age, while that of vascular control remained stable; (iv) during STAND net redundancy of both cardiac and vascular controls was stable with age. Significance: The study confirms the relevance of computing genuine information transfer in cardiovascular control analysis and stresses the importance of evaluating the ITE to quantify the degree of redundancy of physiological mechanisms operating to maintain cardiovascular homeostasis. © 2017 Institute of Physics and Engineering in Medicine.
KW - aging
KW - autonomic nervous system
KW - cardiovascular control
KW - heart rate variability
KW - interaction information
KW - multivariate linear regression model
KW - transfer entropy decomposition
KW - adult
KW - aged
KW - arterial pressure
KW - biological model
KW - breathing
KW - heart rate
KW - human
KW - middle aged
KW - normal human
KW - physiology
KW - systole
KW - young adult
KW - Adult
KW - Aged
KW - Aging
KW - Arterial Pressure
KW - Healthy Volunteers
KW - Heart Rate
KW - Humans
KW - Middle Aged
KW - Models, Cardiovascular
KW - Respiration
KW - Systole
KW - Young Adult
U2 - 10.1088/1361-6579/aa5908
DO - 10.1088/1361-6579/aa5908
M3 - Article
VL - 38
SP - 940
EP - 958
JO - Physiological Measurement
JF - Physiological Measurement
SN - 0967-3334
IS - 5
ER -