Assessing the Role and Optimal Duration of Hormonal Treatment in Association with Salvage Radiation Therapy After Radical Prostatectomy: Results from a Multi-Institutional Study

Nicola Fossati, Daniele Robesti, R. Jeffrey Karnes, Matteo Soligo, Stephen A. Boorjian, Alberto Bossi, Gabriele Coraggio, Nadia Di Muzio, Cesare Cozzarini, Barbara Noris Chiorda, Giorgio Gandaglia, Simone Scarcella, Detlef Bartkowiak, Dirk Böhmer, Shahrokh Shariat, Gregor Goldner, Antonino Battaglia, Steven Joniau, Karin Haustermans, Gert De MeerleerValérie Fonteyne, Piet Ost, Hein Van Poppel, Francesco Montorsi, Thomas Wiegel, Alberto Briganti

Research output: Contribution to journalArticlepeer-review

Abstract

The oncological benefit of hormonal therapy (HT) duration among men receiving salvage radiation therapy for increasing prostate-specific antigen after radical prostatectomy depends on their clinical and pathological characteristics. Our data suggest a significant effect of long-term HT for patients with two or more adverse features. Conversely, short-term HT was sufficient for patients with a single risk factor, whereas patients without any risk factors did not show a significant benefit from concomitant HT.

Original languageEnglish
Pages (from-to)443-449
Number of pages7
JournalEuropean Urology
Volume76
Issue number4
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Biochemical tumor markers
  • Hormonal therapy
  • Neoplasm recurrence
  • Prostatic neoplasms
  • Radiotherapy
  • Salvage therapy

ASJC Scopus subject areas

  • Urology

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