Assessment and management of iron overload in β-thalassaemia major patients during the 21st century: A real-life experience from the Italian Webthal project

Antonio Piga, Filomena Longo, Khaled M. Musallam, Maria Domenica Cappellini, Gian Luca Forni, Giovanni Quarta, Francesco Chiavilli, Francesca Commendatore, Sergio Mulas, Vincenzo Caruso, Renzo Galanello

Research output: Contribution to journalArticle

Abstract

We conducted a cross-sectional study on 924 β-thalassaemia major patients (mean age 30·1 years) treated at nine Italian centres using the webthal software, to evaluate real-life application of iron overload assessment and management standards. Serum ferritin 2 years. Patients who never had a cardiac MRI (CMR) T2* measurement were 2 years. Deferoxamine (22·8%) was more commonly used in patients with Hepatitis C Virus or high serum creatinine. Deferiprone (20·6%) was less commonly prescribed in patients with elevated alanine aminotransferase; while a deferoxamine + deferiprone combination (17·9%) was more commonly used in patients with serum ferritin >2500 ng/ml or CMR T2*

Original languageEnglish
Pages (from-to)872-883
Number of pages12
JournalBritish Journal of Haematology
Volume161
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Iron chelation
  • Iron overload
  • Magnetic resonance imaging
  • Thalassaemia
  • Transfusion

ASJC Scopus subject areas

  • Hematology

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    Piga, A., Longo, F., Musallam, K. M., Cappellini, M. D., Forni, G. L., Quarta, G., Chiavilli, F., Commendatore, F., Mulas, S., Caruso, V., & Galanello, R. (2013). Assessment and management of iron overload in β-thalassaemia major patients during the 21st century: A real-life experience from the Italian Webthal project. British Journal of Haematology, 161(6), 872-883. https://doi.org/10.1111/bjh.12340