TY - JOUR
T1 - Assessment and prevention of cytomegalovirus infection in allogeneic hematopoietic stem cell transplant and in solid organ transplant
T2 - A multidisciplinary consensus conference by the Italian GITMO, SITO, and AMCLI societies
AU - Girmenia, Corrado
AU - Lazzarotto, Tiziana
AU - Bonifazi, Francesca
AU - Patriarca, Francesca
AU - Irrera, Giuseppe
AU - Ciceri, Fabio
AU - Aversa, Franco
AU - Citterio, Franco
AU - Cillo, Umberto
AU - Cozzi, Emanuele
AU - Gringeri, Enrico
AU - Baldanti, Fausto
AU - Cavallo, Rossana
AU - Clerici, Pierangelo
AU - Barosi, Giovanni
AU - Grossi, Paolo
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Cytomegalovirus (CMV) remains a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT) and solid organ transplantation (SOT) recipients. In view of the uncertainties on the assessment and prevention of CMV infection in both transplant procedures, three Italian scientific societies for HSCT and SOT and for Clinical Microbiology appointed a panel of experts to compose a framework of recommendations. Recommendations were derived from a comprehensive analysis of the scientific literature and from a multidisciplinary consensus conference process. The lack of adequate clinical trials focused on certain diagnostic procedures, and antiviral intervention forced the panel to use the methods of consensus for shaping some recommendations. Recommendations concerning the two types of transplant were given for the following issues: assessment of pretransplant CMV serostatus, immunological monitoring after transplant, CMV prophylaxis with antivirals, CMV preemptive strategy, and CMV prophylaxis with immunoglobulin infusion and with adoptive immunotherapy. The questions raised by and the recommendations resulting from this consensus conference project may contribute to the improvement of certain crucial aspects of the management of CMV infections in allo-HSCT and in SOT populations.
AB - Cytomegalovirus (CMV) remains a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT) and solid organ transplantation (SOT) recipients. In view of the uncertainties on the assessment and prevention of CMV infection in both transplant procedures, three Italian scientific societies for HSCT and SOT and for Clinical Microbiology appointed a panel of experts to compose a framework of recommendations. Recommendations were derived from a comprehensive analysis of the scientific literature and from a multidisciplinary consensus conference process. The lack of adequate clinical trials focused on certain diagnostic procedures, and antiviral intervention forced the panel to use the methods of consensus for shaping some recommendations. Recommendations concerning the two types of transplant were given for the following issues: assessment of pretransplant CMV serostatus, immunological monitoring after transplant, CMV prophylaxis with antivirals, CMV preemptive strategy, and CMV prophylaxis with immunoglobulin infusion and with adoptive immunotherapy. The questions raised by and the recommendations resulting from this consensus conference project may contribute to the improvement of certain crucial aspects of the management of CMV infections in allo-HSCT and in SOT populations.
KW - cytomegalovirus
KW - diagnosis
KW - hematopoietic stem cell transplant
KW - preemptive therapy
KW - prophylaxis
KW - solid organ transplant
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U2 - 10.1111/ctr.13666
DO - 10.1111/ctr.13666
M3 - Review article
C2 - 31310687
AN - SCOPUS:85070677535
JO - Clinical Transplantation
JF - Clinical Transplantation
SN - 0902-0063
M1 - e13666
ER -