Assessment and treatment of severe pancreatitis. Protease inhibitor

Claudio Bassi, Massimo Falconi, Erminia Caldiron, Roberto Salvia, Nora Sartori, Giovanni Butturini, Conrado Contro, Stefano Marcucci, Luca Casetti, Paolo Pederzoli

Research output: Contribution to journalArticlepeer-review

Abstract

From the theoretical point of view, antiproteolytic therapy would seem to be the rationale for acute pancreatitis management. Unfortunately, clinical human trials studying the role of antiproteases in the treatment of acute pancreatitis differ in several respects in terms of their basic design. As a consequence, any form of homogeneous analysis of the reported data as a whole is impossible. Considering the data emerging from a meta-analysis of five trials a rational use of antiproteases may result in a reduction of complications requiring surgery and of patient management costs only in selected cases, meaning by that severe and necrotic forms. As regards presumptive applications, over 400 patients were prospectively tested versus placebo in a double-blind trial with the aim of preventing acute pancreatitis after ERCP. The complication incidence was significantly lower among the pretreated patients; anyway, also in this field of protease inhibitor clinical application it is necessary to identify the patients with the greatest risk to develop post-ERCP acute pancreatitis. In conclusion, antiproteases can still play a role when given prophylactically or when used in the very early phases of the disease; moreover a 'multiple drugs approach' (including, for example, suitable antibiotics) seems to represent nowadays the most modern and rational treatment of acute pancreatitis.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalDigestion
Volume60
Issue numberSUPPL. 1
Publication statusPublished - Feb 1999

Keywords

  • Multiple drugs approach
  • Pancreatitis, assessment and treatment
  • Post-ERCP acute pancreatitis
  • Protease inhibitor, clinical applications

ASJC Scopus subject areas

  • Gastroenterology

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