Assessment of a continuous blood gas monitoring system in animals during circulatory stress

Sandro Gelsomino, Roberto Lorusso, Ugolino Livi, Stefano Romagnoli, Salvatore M. Romano, Rocco Carella, Fabiana Lucà, Giuseppe Billè, Francesco Matteucci, Attilio Renzulli, Gil Bolotin, Giuseppe De Cicco, Pierluigi Stefàno, Jos Maessen, Gian F. Gensini

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Background: The study was aimed to determine the measurement accuracy of The CDI™ blood parameter monitoring system 500 (Terumo Cardiovascular Systems Corporation, Ann Arbor MI) in the real-time continuous measurement of arterial blood gases under different cardiocirculatory stress conditions. Methods: Inotropic stimulation (Dobutamine 2.5 and 5 μg/kg/min), vasoconstriction (Arginine-vasopressin 4, 8 and 16 IU/h), hemorrhage (-10%, -20%, -35%, and -50% of the theoretical volemia), and volume resuscitation were induced in ten swine (57.4 ± 10.7 Kg).Intermittent blood gas assessments were carried out using a routine gas analyzer at any experimental phase and compared with values obtained at the same time settings during continuous monitoring with CDI™ 500 system. The Bland-Altman analysis was employed.Results: Bias and precision for pO2 were - 0.06 kPa and 0.22 kPa, respectively (r2 = 0.96); pCO2 - 0.02 kPa and 0.15 kPa, respectively; pH -0.001 and 0.01 units, respectively ( r2 = 0.96). The analysis showed very good agreement for SO2 (bias 0.04,precision 0.33, r2 = 0.95), Base excess (bias 0.04,precision 0.28, r2 = 0.98), HCO3 (bias 0.05,precision 0.62, r2 = 0.92),hemoglobin (bias 0.02,precision 0.23, r2 = 0.96) and K+ (bias 0.02, precision 0.27, r2 = 0.93). The sensor was reliable throughout the experiment during hemodynamic variations.Conclusions: Continuous blood gas analysis with the CDI™ 500 system was reliable and it might represent a new useful tool to accurately and timely monitor gas exchange in critically ill patients. Nonetheless, our findings need to be confirmed by larger studies to prove its reliability in the clinical setting.

Original languageEnglish
Article number1471
JournalBMC Anesthesiology
Publication statusPublished - Jan 11 2011

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Gelsomino, S., Lorusso, R., Livi, U., Romagnoli, S., Romano, S. M., Carella, R., Lucà, F., Billè, G., Matteucci, F., Renzulli, A., Bolotin, G., De Cicco, G., Stefàno, P., Maessen, J., & Gensini, G. F. (2011). Assessment of a continuous blood gas monitoring system in animals during circulatory stress. BMC Anesthesiology, 11, [1471].