Assessment of angiogenesis by CD105 and nestin expression in peritumor tissue of glioblastoma

Gigliola Sica, Gina Lama, Carmelo Anile, Maria Concetta Geloso, Giuseppe La Torre, Pasquale De Bonis, Giulio Maira, Libero Lauriola, Meena Jhanwar-Uniyal, Annunziato Mangiola

Research output: Contribution to journalArticlepeer-review

Abstract

Angiogenesis in the peritumor tissue of glioblastoma (GBM) is still an open field of research. This study investigates neovascularization in the tumor surrounding areas by examining CD105 and nestin expression along with microvessel density (MVD) with the aim of establishing their possible prognostic significance. Angiogenesis was also confirmed by investigating, in vessel walls, the presence of pericytes, which are multipotent stem cells, expressing α-smooth muscle actin (α-SMA). In our study, including 40 GBM patients, tissue samples were obtained from tumors (first area) and white matter at a distance

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalInternational Journal of Oncology
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Angiogenesis
  • CD105
  • Glioblastoma
  • Microvessel density
  • Nestin
  • Peritumor tissue

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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