Assessment of anti-prothrombin antibodies in thrombosis complicating inflammatory bowel diseases

Simone Saibeni, Maria J. Etchevers, Dolors Tassies, Julián Panés, Joan C. Reverter, Silvio Danese, Josep M. Piqué, Savino Bruno, Maurizio Vecchi, Antonio Gasbarrini, Miquel Sans

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: In inflammatory bowel diseases (IBD), risk of thrombosis and production of antibodies are increased. In autoimmune and inflammatory disorders, a role of anti-prothrombin (aPT) antibodies in developing thrombosis has been hypothesised. The aim of the study is to evaluate the prevalence of aPT antibodies in IBD patients, with and without thrombosis. Methods: Thirty-three IBD patients with thrombosis, 33 IBD patients without thrombosis matched for sex, age, diagnosis and disease activity and 66 sex- and age-matched healthy controls were enrolled. Thrombosis was considered recent when blood sample was obtained within 3 months from the event. Results: Prevalence of aPT antibodies in thrombotic IBD patients (3/33, 9.1 %), non-thrombotic IBD patients (4/33, 12.1 %) and in healthy subjects (3/66, 4.5 %) did not result significantly different (p = 0.377). The prevalence of aPT antibodies was more frequent in ulcerative colitis (6/32, 18.7 %) than in Crohn's disease (1/34, 2.9 %) and healthy controls (p = 0.022). Among thrombotic IBD patients, the prevalence of aPT antibodies was higher in those with recent (2/9, 22.2 %) than in those with previous thrombosis (1/24, 4.2 %) (p = 0.103). All thrombotic IBD patients with aPT antibodies were affected by ulcerative colitis with previous history of deep venous thrombosis. Conclusions: aPT antibodies do not appear to play a relevant role in thrombosis complicating IBD course. A possible association in ulcerative colitis patients with DVT could not be excluded.

Original languageEnglish
Pages (from-to)1281-1286
Number of pages6
JournalInternational Journal of Colorectal Disease
Volume28
Issue number9
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Antibodies
  • Crohn's disease
  • Prothrombin
  • Thrombosis
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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