Assessment of arterial and cardiopulmonary baroreflex gains from simultaneous recordings of spontaneous cardiovascular and respiratory variability

Daniela Lucini, Alberto Porta, Olivia Milani, Giuseppe Baselli, Massimo Pagani

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objectives. In usual models of cardiovascular regulation, arterial pressure drives RR interval through a simple baroreflex, and the influence of respiration is dismissed. We examined the applicability of a trivariate autoregressive model to obtain separate values of the gain of the arterial and non-arterial, i.e. cardiopulmonary, components of the lumped baroreflex, employing spontaneous RR interval, systolic arterial pressure and respiration variability. Design. We studied 30 normal subjects (age 37 ± 1 years), both at rest and during standing, a condition known to enhance sympathetic activity while reducing venous return. Electrocardiogram was obtained by telemetry, arterial pressure by Finapres and respiration with a piezoelectric respiratory belt. Data were acquired with a PC and processed with an ad hoc Windows program. Methods. We employed an additive and a linear multivariate approach to approximate overall gain of the arterial pressure-heart beat period baroreflex (α(lumped)) and of its arterial (α(art)) and non-arterial, i.e. cardiopulmonary (α(cp)), components, from continuous beat-by-beat series of RR interval, systolic arterial pressure variability and respiration, without using any non-physiological intervention. Results. The overall baroreflex gain at rest (α(lumped) = 23.7 ± 3.4 ms/mmHg) was subdivided into arterial (α(art) = 5.2 ± 1.0 ms/mmHg) and cardiopulmonary (α(cp) = 18.5 ± 3.2 ms/mmHg) components. During active orthostatism, α(lumped) was diminished to 10.0 ± 2.2 ms/mmHg. In addition, standing selectively reduced α(cp) to 4.8 ± 1.3 ms/mmHg, while α(art) was not significantly changed. Conclusions. A trivariate autoregressive model, that considers explicitly the influence of respiration, can subdivide overall, lumped, arterial pressure-heart period baroreflex gain, into two separate components, α(art) and α(cp). Only the latter is reduced by active orthostatism. (C) Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalJournal of Hypertension
Volume18
Issue number3
Publication statusPublished - 2000

Fingerprint

Baroreflex
Arterial Pressure
Respiration
Cardiovascular Models
Blood Pressure
Telemetry
Electrocardiography

Keywords

  • Arterial baroreflex
  • Arterial pressure
  • Cardiopulmonary baroreflex
  • Heart rate
  • Modelling
  • Orthostatism
  • Posture
  • Respiration
  • Spectral analysis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Assessment of arterial and cardiopulmonary baroreflex gains from simultaneous recordings of spontaneous cardiovascular and respiratory variability. / Lucini, Daniela; Porta, Alberto; Milani, Olivia; Baselli, Giuseppe; Pagani, Massimo.

In: Journal of Hypertension, Vol. 18, No. 3, 2000, p. 281-286.

Research output: Contribution to journalArticle

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title = "Assessment of arterial and cardiopulmonary baroreflex gains from simultaneous recordings of spontaneous cardiovascular and respiratory variability",
abstract = "Objectives. In usual models of cardiovascular regulation, arterial pressure drives RR interval through a simple baroreflex, and the influence of respiration is dismissed. We examined the applicability of a trivariate autoregressive model to obtain separate values of the gain of the arterial and non-arterial, i.e. cardiopulmonary, components of the lumped baroreflex, employing spontaneous RR interval, systolic arterial pressure and respiration variability. Design. We studied 30 normal subjects (age 37 ± 1 years), both at rest and during standing, a condition known to enhance sympathetic activity while reducing venous return. Electrocardiogram was obtained by telemetry, arterial pressure by Finapres and respiration with a piezoelectric respiratory belt. Data were acquired with a PC and processed with an ad hoc Windows program. Methods. We employed an additive and a linear multivariate approach to approximate overall gain of the arterial pressure-heart beat period baroreflex (α(lumped)) and of its arterial (α(art)) and non-arterial, i.e. cardiopulmonary (α(cp)), components, from continuous beat-by-beat series of RR interval, systolic arterial pressure variability and respiration, without using any non-physiological intervention. Results. The overall baroreflex gain at rest (α(lumped) = 23.7 ± 3.4 ms/mmHg) was subdivided into arterial (α(art) = 5.2 ± 1.0 ms/mmHg) and cardiopulmonary (α(cp) = 18.5 ± 3.2 ms/mmHg) components. During active orthostatism, α(lumped) was diminished to 10.0 ± 2.2 ms/mmHg. In addition, standing selectively reduced α(cp) to 4.8 ± 1.3 ms/mmHg, while α(art) was not significantly changed. Conclusions. A trivariate autoregressive model, that considers explicitly the influence of respiration, can subdivide overall, lumped, arterial pressure-heart period baroreflex gain, into two separate components, α(art) and α(cp). Only the latter is reduced by active orthostatism. (C) Lippincott Williams and Wilkins.",
keywords = "Arterial baroreflex, Arterial pressure, Cardiopulmonary baroreflex, Heart rate, Modelling, Orthostatism, Posture, Respiration, Spectral analysis",
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T1 - Assessment of arterial and cardiopulmonary baroreflex gains from simultaneous recordings of spontaneous cardiovascular and respiratory variability

AU - Lucini, Daniela

AU - Porta, Alberto

AU - Milani, Olivia

AU - Baselli, Giuseppe

AU - Pagani, Massimo

PY - 2000

Y1 - 2000

N2 - Objectives. In usual models of cardiovascular regulation, arterial pressure drives RR interval through a simple baroreflex, and the influence of respiration is dismissed. We examined the applicability of a trivariate autoregressive model to obtain separate values of the gain of the arterial and non-arterial, i.e. cardiopulmonary, components of the lumped baroreflex, employing spontaneous RR interval, systolic arterial pressure and respiration variability. Design. We studied 30 normal subjects (age 37 ± 1 years), both at rest and during standing, a condition known to enhance sympathetic activity while reducing venous return. Electrocardiogram was obtained by telemetry, arterial pressure by Finapres and respiration with a piezoelectric respiratory belt. Data were acquired with a PC and processed with an ad hoc Windows program. Methods. We employed an additive and a linear multivariate approach to approximate overall gain of the arterial pressure-heart beat period baroreflex (α(lumped)) and of its arterial (α(art)) and non-arterial, i.e. cardiopulmonary (α(cp)), components, from continuous beat-by-beat series of RR interval, systolic arterial pressure variability and respiration, without using any non-physiological intervention. Results. The overall baroreflex gain at rest (α(lumped) = 23.7 ± 3.4 ms/mmHg) was subdivided into arterial (α(art) = 5.2 ± 1.0 ms/mmHg) and cardiopulmonary (α(cp) = 18.5 ± 3.2 ms/mmHg) components. During active orthostatism, α(lumped) was diminished to 10.0 ± 2.2 ms/mmHg. In addition, standing selectively reduced α(cp) to 4.8 ± 1.3 ms/mmHg, while α(art) was not significantly changed. Conclusions. A trivariate autoregressive model, that considers explicitly the influence of respiration, can subdivide overall, lumped, arterial pressure-heart period baroreflex gain, into two separate components, α(art) and α(cp). Only the latter is reduced by active orthostatism. (C) Lippincott Williams and Wilkins.

AB - Objectives. In usual models of cardiovascular regulation, arterial pressure drives RR interval through a simple baroreflex, and the influence of respiration is dismissed. We examined the applicability of a trivariate autoregressive model to obtain separate values of the gain of the arterial and non-arterial, i.e. cardiopulmonary, components of the lumped baroreflex, employing spontaneous RR interval, systolic arterial pressure and respiration variability. Design. We studied 30 normal subjects (age 37 ± 1 years), both at rest and during standing, a condition known to enhance sympathetic activity while reducing venous return. Electrocardiogram was obtained by telemetry, arterial pressure by Finapres and respiration with a piezoelectric respiratory belt. Data were acquired with a PC and processed with an ad hoc Windows program. Methods. We employed an additive and a linear multivariate approach to approximate overall gain of the arterial pressure-heart beat period baroreflex (α(lumped)) and of its arterial (α(art)) and non-arterial, i.e. cardiopulmonary (α(cp)), components, from continuous beat-by-beat series of RR interval, systolic arterial pressure variability and respiration, without using any non-physiological intervention. Results. The overall baroreflex gain at rest (α(lumped) = 23.7 ± 3.4 ms/mmHg) was subdivided into arterial (α(art) = 5.2 ± 1.0 ms/mmHg) and cardiopulmonary (α(cp) = 18.5 ± 3.2 ms/mmHg) components. During active orthostatism, α(lumped) was diminished to 10.0 ± 2.2 ms/mmHg. In addition, standing selectively reduced α(cp) to 4.8 ± 1.3 ms/mmHg, while α(art) was not significantly changed. Conclusions. A trivariate autoregressive model, that considers explicitly the influence of respiration, can subdivide overall, lumped, arterial pressure-heart period baroreflex gain, into two separate components, α(art) and α(cp). Only the latter is reduced by active orthostatism. (C) Lippincott Williams and Wilkins.

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KW - Arterial pressure

KW - Cardiopulmonary baroreflex

KW - Heart rate

KW - Modelling

KW - Orthostatism

KW - Posture

KW - Respiration

KW - Spectral analysis

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