Abstract
Objectives. In usual models of cardiovascular regulation, arterial pressure drives RR interval through a simple baroreflex, and the influence of respiration is dismissed. We examined the applicability of a trivariate autoregressive model to obtain separate values of the gain of the arterial and non-arterial, i.e. cardiopulmonary, components of the lumped baroreflex, employing spontaneous RR interval, systolic arterial pressure and respiration variability. Design. We studied 30 normal subjects (age 37 ± 1 years), both at rest and during standing, a condition known to enhance sympathetic activity while reducing venous return. Electrocardiogram was obtained by telemetry, arterial pressure by Finapres and respiration with a piezoelectric respiratory belt. Data were acquired with a PC and processed with an ad hoc Windows program. Methods. We employed an additive and a linear multivariate approach to approximate overall gain of the arterial pressure-heart beat period baroreflex (α(lumped)) and of its arterial (α(art)) and non-arterial, i.e. cardiopulmonary (α(cp)), components, from continuous beat-by-beat series of RR interval, systolic arterial pressure variability and respiration, without using any non-physiological intervention. Results. The overall baroreflex gain at rest (α(lumped) = 23.7 ± 3.4 ms/mmHg) was subdivided into arterial (α(art) = 5.2 ± 1.0 ms/mmHg) and cardiopulmonary (α(cp) = 18.5 ± 3.2 ms/mmHg) components. During active orthostatism, α(lumped) was diminished to 10.0 ± 2.2 ms/mmHg. In addition, standing selectively reduced α(cp) to 4.8 ± 1.3 ms/mmHg, while α(art) was not significantly changed. Conclusions. A trivariate autoregressive model, that considers explicitly the influence of respiration, can subdivide overall, lumped, arterial pressure-heart period baroreflex gain, into two separate components, α(art) and α(cp). Only the latter is reduced by active orthostatism. (C) Lippincott Williams and Wilkins.
| Original language | English |
|---|---|
| Pages (from-to) | 281-286 |
| Number of pages | 6 |
| Journal | Journal of Hypertension |
| Volume | 18 |
| Issue number | 3 |
| Publication status | Published - 2000 |
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Keywords
- Arterial baroreflex
- Arterial pressure
- Cardiopulmonary baroreflex
- Heart rate
- Modelling
- Orthostatism
- Posture
- Respiration
- Spectral analysis
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology
Cite this
Assessment of arterial and cardiopulmonary baroreflex gains from simultaneous recordings of spontaneous cardiovascular and respiratory variability. / Lucini, Daniela; Porta, Alberto; Milani, Olivia; Baselli, Giuseppe; Pagani, Massimo.
In: Journal of Hypertension, Vol. 18, No. 3, 2000, p. 281-286.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of arterial and cardiopulmonary baroreflex gains from simultaneous recordings of spontaneous cardiovascular and respiratory variability
AU - Lucini, Daniela
AU - Porta, Alberto
AU - Milani, Olivia
AU - Baselli, Giuseppe
AU - Pagani, Massimo
PY - 2000
Y1 - 2000
N2 - Objectives. In usual models of cardiovascular regulation, arterial pressure drives RR interval through a simple baroreflex, and the influence of respiration is dismissed. We examined the applicability of a trivariate autoregressive model to obtain separate values of the gain of the arterial and non-arterial, i.e. cardiopulmonary, components of the lumped baroreflex, employing spontaneous RR interval, systolic arterial pressure and respiration variability. Design. We studied 30 normal subjects (age 37 ± 1 years), both at rest and during standing, a condition known to enhance sympathetic activity while reducing venous return. Electrocardiogram was obtained by telemetry, arterial pressure by Finapres and respiration with a piezoelectric respiratory belt. Data were acquired with a PC and processed with an ad hoc Windows program. Methods. We employed an additive and a linear multivariate approach to approximate overall gain of the arterial pressure-heart beat period baroreflex (α(lumped)) and of its arterial (α(art)) and non-arterial, i.e. cardiopulmonary (α(cp)), components, from continuous beat-by-beat series of RR interval, systolic arterial pressure variability and respiration, without using any non-physiological intervention. Results. The overall baroreflex gain at rest (α(lumped) = 23.7 ± 3.4 ms/mmHg) was subdivided into arterial (α(art) = 5.2 ± 1.0 ms/mmHg) and cardiopulmonary (α(cp) = 18.5 ± 3.2 ms/mmHg) components. During active orthostatism, α(lumped) was diminished to 10.0 ± 2.2 ms/mmHg. In addition, standing selectively reduced α(cp) to 4.8 ± 1.3 ms/mmHg, while α(art) was not significantly changed. Conclusions. A trivariate autoregressive model, that considers explicitly the influence of respiration, can subdivide overall, lumped, arterial pressure-heart period baroreflex gain, into two separate components, α(art) and α(cp). Only the latter is reduced by active orthostatism. (C) Lippincott Williams and Wilkins.
AB - Objectives. In usual models of cardiovascular regulation, arterial pressure drives RR interval through a simple baroreflex, and the influence of respiration is dismissed. We examined the applicability of a trivariate autoregressive model to obtain separate values of the gain of the arterial and non-arterial, i.e. cardiopulmonary, components of the lumped baroreflex, employing spontaneous RR interval, systolic arterial pressure and respiration variability. Design. We studied 30 normal subjects (age 37 ± 1 years), both at rest and during standing, a condition known to enhance sympathetic activity while reducing venous return. Electrocardiogram was obtained by telemetry, arterial pressure by Finapres and respiration with a piezoelectric respiratory belt. Data were acquired with a PC and processed with an ad hoc Windows program. Methods. We employed an additive and a linear multivariate approach to approximate overall gain of the arterial pressure-heart beat period baroreflex (α(lumped)) and of its arterial (α(art)) and non-arterial, i.e. cardiopulmonary (α(cp)), components, from continuous beat-by-beat series of RR interval, systolic arterial pressure variability and respiration, without using any non-physiological intervention. Results. The overall baroreflex gain at rest (α(lumped) = 23.7 ± 3.4 ms/mmHg) was subdivided into arterial (α(art) = 5.2 ± 1.0 ms/mmHg) and cardiopulmonary (α(cp) = 18.5 ± 3.2 ms/mmHg) components. During active orthostatism, α(lumped) was diminished to 10.0 ± 2.2 ms/mmHg. In addition, standing selectively reduced α(cp) to 4.8 ± 1.3 ms/mmHg, while α(art) was not significantly changed. Conclusions. A trivariate autoregressive model, that considers explicitly the influence of respiration, can subdivide overall, lumped, arterial pressure-heart period baroreflex gain, into two separate components, α(art) and α(cp). Only the latter is reduced by active orthostatism. (C) Lippincott Williams and Wilkins.
KW - Arterial baroreflex
KW - Arterial pressure
KW - Cardiopulmonary baroreflex
KW - Heart rate
KW - Modelling
KW - Orthostatism
KW - Posture
KW - Respiration
KW - Spectral analysis
UR - http://www.scopus.com/inward/record.url?scp=0034010098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034010098&partnerID=8YFLogxK
M3 - Article
C2 - 10726714
AN - SCOPUS:0034010098
VL - 18
SP - 281
EP - 286
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 3
ER -