Assessment of arterial stiffness for clinical and epidemiological studies: Methodological considerations for validation and entry into the European Renal and Cardiovascular Medicine registry

Pierre Boutouyrie, Danilo Fliser, David Goldsmith, Adrian Covic, Andrzej Wiecek, Alberto Ortiz, Alberto Martinez-Castelao, Bengt Lindholm, Ziad A. Massy, Gultekin Suleymanlar, Rosa Sicari, Luna Gargani, Gianfranco Parati, Francesca Mallamaci, Carmine Zoccali, Gerard M. London

Research output: Contribution to journalArticle

Abstract

Epidemiological studies have highlighted the role of arterial stiffness as a risk factor for development of cardiovascular (CV) diseases. Moreover, aortic stiffness has been shown to be a significant predictive factor of all-cause and CV mortality in different populations including patients with end-stage renal disease. Pulse-wave velocity (PWV) is the most widely used technique to assess arterial stiffness. Although PWV can be measured on any artery or between any arterial sites, only carotid-to-femoral PWV, representing stiffness of the aorta and iliofemoral axes, has been shown to have predictive value for morbidity and mortality. The several available commercial devices differ according to the type of signal (pressure, distension, flow) or by recording both sites simultaneously or using ECG synchronization. It is also possible to directly measure arterial diameter changes during the cardiac cycle and link them to local pulse-pressure changes, which provides the pressure-diameter relationship and stress-strain relationship if arterial wall thickness is also measured. These techniques are based on high-precision vascular echo tracking or magnetic resonance imaging and applanation tonometry. This paper summarizes the basic principles of arterial haemodynamics and various methodologies to assess stiffness and the latest consensus recommendations for clinical applications.

Original languageEnglish
Pages (from-to)232-239
Number of pages8
JournalNephrology Dialysis Transplantation
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • aortic pressure
  • arterial stiffness
  • elastic modulus
  • pulse-wave velocity

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Fingerprint Dive into the research topics of 'Assessment of arterial stiffness for clinical and epidemiological studies: Methodological considerations for validation and entry into the European Renal and Cardiovascular Medicine registry'. Together they form a unique fingerprint.

Cite this