Assessment of baroreflex contribution to spontaneous blood pressure-heart rate coupling by cross mutual information

M. Di Rienzo, D. Hoyer, P. Castiglioni, G. Parati, B. Pompe, U. Zwiener

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A novel procedure is proposed to 1) quantify the level of physiological coupling existing between arterial blood pressure and heart rate variability during spontaneous behavior and 2) identify the relative contribution of the arterial baroreflex in the production of this coupling. The procedure is based on the estimation of the Cross-Mutual Information (CMI) between systolic blood pressure (SBP) and pulse interval (PI, the reciprocal of heart rate) beat-to-beat values. Use of this statistical function provides a quantification of both linear and nonlinear components of the coupling between variables. The procedure has been preliminarily applied to data collected in two spontaneously behaving cats before and seven days after the opening of the baroreflex loop. This allowed us to determine the baseline level of the SBP-PI coupling in intact conditions and the remaining fraction of SBP-PI coupling surviving deactivation of the baroreflex control function. We observed that in intact animals the cumulative physiological level of linear and nonlinear coupling between SBP and PI corresponded to 50% and 35%, respectively, of the theoretical maximal coupling. After removal of the baroreflex influence CMI values drastically dropped with respect to the above baseline values (-76% and -67%, respectively). Thus, use of CMI indicates that the arterial baroreflex is the major determinant of the SBP-PI link, accounting for about 2/3 of the total measured coupling existing between these variables.

Original languageEnglish
Title of host publicationAnnual Reports of the Research Reactor Institute, Kyoto University
Pages589-591
Number of pages3
Volume1
Publication statusPublished - 2001
Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Istanbul, Turkey
Duration: Oct 25 2001Oct 28 2001

Other

Other23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CountryTurkey
CityIstanbul
Period10/25/0110/28/01

Keywords

  • Baroreflex
  • Blood pressure variability
  • Cardiovascular regulation
  • Neural control
  • Nonlinearity

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Mechanical Engineering

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  • Cite this

    Di Rienzo, M., Hoyer, D., Castiglioni, P., Parati, G., Pompe, B., & Zwiener, U. (2001). Assessment of baroreflex contribution to spontaneous blood pressure-heart rate coupling by cross mutual information. In Annual Reports of the Research Reactor Institute, Kyoto University (Vol. 1, pp. 589-591)