Assessment of Biochemical Recurrence Rate in Patients With Pathologically Confirmed Insignificant Prostate Cancer

Umberto Capitanio, Sasha Ahyai, Markus Graefen, Claudio Jeldres, Shahrokh F. Shariat, Andreas Erbersdobler, Thorsten Schlomm, Alexander Haese, Thomas Steuber, Hans Heinzer, Paul Perrotte, François Péloquin, Daniel Pharand, Philippe Arjane, Hartwig Huland, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To examine the rate of biochemical recurrence (BCR) in patients with pathologically confirmed insignificant prostate cancer (PIPCa). Methods: A total of 1358 patients underwent open retropubic radical prostatectomy at the University Medical Center Eppendorf in Hamburg, Germany, and their specimens were whole-mounted, step-sectioned, and subjected to computer-based three-dimensional reconstruction. We identified patients who fulfilled the Epstein criteria for definition of PIPCa (tumor volume ≤0.5 mL, Gleason score ≤6, organ-confined disease) and we compared the BCR-free rates between the PIPCa and non-PIPCa groups. Results: Pathologically confirmed insignificant prostate cancer was found in 69 patients (5%). At 1, 2, 5, and 10 years, the BCR-free rate for PIPCa patients was 100% vs, respectively, 97%, 91%, 74%, and 38% for other patients (log-rank P

Original languageEnglish
Pages (from-to)1208-1211
Number of pages4
JournalUrology
Volume72
Issue number6
DOIs
Publication statusPublished - Dec 2008

ASJC Scopus subject areas

  • Urology

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