TY - JOUR
T1 - Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure
T2 - A clinical appraisal
AU - Perrone-Filardi, Pasquale
AU - Paolillo, Stefania
AU - Dellegrottaglie, Santo
AU - Gargiulo, Paola
AU - Savarese, Gianluigi
AU - Marciano, Caterina
AU - Casaretti, Laura
AU - Cecere, Milena
AU - Musella, Francesca
AU - Pirozzi, Elisabetta
AU - Parente, Antonio
AU - Cuocolo, Alberto
PY - 2011/11
Y1 - 2011/11
N2 - Cardiac sympathetic activity can be assessed by 123I-labelled meta-iodobenzylguanidine (MIBG) scintigraphy. Abnormalities of sympathetic cardiac activity have been shown in patients with heart failure, resulting in reduced MIBG uptake. Abnormal MIBG uptake predicts cardiac death, arrhythmias and all-cause mortality in patients with heart failure with a prognostic power incremental to that of conventional risk markers, and may identify patients at low risk of arrhythmias despite current guideline indications for implantable cardioverter defibrillator or patients at high risk for arrhythmias not fulfilling implantable cardioverter defibrillator indications. Prospective outcome studies are needed to assess whether MIBG imaging will have an impact on the mortality and morbidity of patients with heart failure.
AB - Cardiac sympathetic activity can be assessed by 123I-labelled meta-iodobenzylguanidine (MIBG) scintigraphy. Abnormalities of sympathetic cardiac activity have been shown in patients with heart failure, resulting in reduced MIBG uptake. Abnormal MIBG uptake predicts cardiac death, arrhythmias and all-cause mortality in patients with heart failure with a prognostic power incremental to that of conventional risk markers, and may identify patients at low risk of arrhythmias despite current guideline indications for implantable cardioverter defibrillator or patients at high risk for arrhythmias not fulfilling implantable cardioverter defibrillator indications. Prospective outcome studies are needed to assess whether MIBG imaging will have an impact on the mortality and morbidity of patients with heart failure.
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U2 - 10.1136/heartjnl-2011-300343
DO - 10.1136/heartjnl-2011-300343
M3 - Article
C2 - 21917663
AN - SCOPUS:80055113188
VL - 97
SP - 1828
EP - 1833
JO - Heart
JF - Heart
SN - 1355-6037
IS - 22
ER -