Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: A clinical appraisal

Pasquale Perrone-Filardi, Stefania Paolillo, Santo Dellegrottaglie, Paola Gargiulo, Gianluigi Savarese, Caterina Marciano, Laura Casaretti, Milena Cecere, Francesca Musella, Elisabetta Pirozzi, Antonio Parente, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac sympathetic activity can be assessed by 123I-labelled meta-iodobenzylguanidine (MIBG) scintigraphy. Abnormalities of sympathetic cardiac activity have been shown in patients with heart failure, resulting in reduced MIBG uptake. Abnormal MIBG uptake predicts cardiac death, arrhythmias and all-cause mortality in patients with heart failure with a prognostic power incremental to that of conventional risk markers, and may identify patients at low risk of arrhythmias despite current guideline indications for implantable cardioverter defibrillator or patients at high risk for arrhythmias not fulfilling implantable cardioverter defibrillator indications. Prospective outcome studies are needed to assess whether MIBG imaging will have an impact on the mortality and morbidity of patients with heart failure.

Original languageEnglish
Pages (from-to)1828-1833
Number of pages6
JournalHeart
Volume97
Issue number22
DOIs
Publication statusPublished - Nov 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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